Publications by authors named "Patience J Okokon"
Antiplasmodial activity and cytotoxicity of ethanol extract of root.
Avicenna J Phytomed
January 2017
Objective: root decoction that has been traditionally used for the treatment of malaria by various tribes in Nigeria, was evaluated for antimalarial potential against malaria parasites using and models.
Materials And Methods: The root extract of was investigated for antimalarial activity against in mice using rodent malaria models; suppressive, prophylactic and curative tests and antiplasmodial activity against chloroquine-sensitive (Pf 3D7) and resistant (Pf INDO) strains of using SYBR green assay method. Median lethal dose and cytotoxic activity against HeLa and HEKS cells were assessed and phytochemical screening was also carried out using standard procedures.
Context: Homalium letestui Pellegr (Flacourtiaceae) is used in various decoctions traditionally by the Ibibios of the Niger Delta of Nigeria to treat stomach ulcer, malaria and other inflammatory diseases, as well as an aphrodisiac.
Objective: To investigate the anti-inflammatory and antinociceptive activities of the stem extract of the plant.
Materials And Methods: The ethanol stem extract (500, 750, 1000 mg/kg, i.