A Pilot Open-Label Randomized Study to Evaluate the Safety, Tolerability, and Acceptability of the IntegriMedical® Needle Free Injection System versus a Conventional Needle-Based System in Healthy Volunteers, Using Normal Saline as a Placebo.

Purpose: The study aimed to assess the safety, tolerability, and acceptability of the IntegriMedical® Needle Free Injection System (IM-NFIS) compared to conventional hypodermic needle injections (CHN) in healthy adult subjects across multiple injection sites.

Patients And Methods: Thirty healthy male subjects aged 18-45 years were enrolled in this open-label study. Each subject received both NF and CHN injections at five different sites (forearm, abdomen, thigh, buttocks, and arm).

Dissipation and persistence behaviour of fipronil and its metabolites in chilli fruits using GC-ECD, confirmed by GC-MS, under semi-arid conditions.

Chilli, one of the most popular vegetables in the world is infested by many insect-pests and diseases. Fipronil, a phenylpyrazole class insecticide is used to manage insect-pests on chilli. The present study aimed to analyze the dissipation patterns and residual concentrations of the fipronil and its metabolites in chilli fruits during the Kharif season of 2020-21, in semi-arid environment.

Intranasal Insulin for Treatment of Persistent Post-COVID-19 Olfactory Dysfunction: A Scoping Review.

Olfactory dysfunction has emerged as a prominent symptom of COVID-19, persisting in a subset of patients even after recovery. This scoping review aims to explore the potential of intranasal insulin as a treatment modality for persistent post-COVID-19 olfactory dysfunction. A comprehensive literature search was conducted to gather relevant studies examining the role of intranasal insulin in treating olfactory dysfunction, particularly in post-COVID-19 cases.

A Comprehensive Physiotherapeutic Intervention for Complex Proximal Tibia Fracture With Ilizarov Fixator and Foot Drop in 18-Year-Old Adult: A Case Report.

The susceptibility of the tibia to fractures arises from its exposed position, making it a commonly affected area. The proximal tibia exhibits a wide metaphyseal region that gradually narrows distally, forming a triangular shape. The extended tibia shaft articulates with the fibula, talus, and distal femur.

Toward a Universal Definition of Etiologies in Heart Failure: Categorizing Causes and Advancing Registry Science.

Heart failure (HF) is a well-described final common pathway for a broad range of diseases however substantial confusion exists regarding how to describe, study, and track these underlying etiologic conditions. We describe (1) the overlap in HF etiologies, comorbidities, and case definitions as currently used in HF registries led or managed by members of the global HF roundtable; (2) strategies to improve the quality of evidence on etiologies and modifiable risk factors of HF in registries; and (3) opportunities to use clinical HF registries as a platform for public health surveillance, implementation research, and randomized registry trials to reduce the global burden of noncommunicable diseases. Investment and collaboration among countries to improve the quality of evidence in global HF registries could contribute to achieving global health targets to reduce noncommunicable diseases and overall improvements in population health.

Predicting the Length of Stay of Cardiac Patients Based on Pre-Operative Variables-Bayesian Models vs. Machine Learning Models.

Length of stay (LoS) prediction is deemed important for a medical institution's operational and logistical efficiency. Sound estimates of a patient's stay increase clinical preparedness and reduce aberrations. Various statistical methods and techniques are used to quantify and predict the LoS of a patient based on pre-operative clinical features.

Scope of an Integrative Neurophysiotherapy Approach in Achieving Gross Motor Milestones in a Child with Meningitis: A Case Report.

Meningitis caused by bacteria, which is an inflammation of the meninges affecting the pia, arachnoid, and subarachnoid space, is still one of the leading causes of death and morbidity in infants and young children. , group B streptococcus (GBS), type B (Hib), , and have been found to be the most frequent causative agents. Infants and children can have modest, fluctuating, non-specific, or even absent clinical signs of bacterial meningitis.

Transformations of bamboo into bioethanol through biorefinery.

The increasing demand for energy has prompted scholars to research alternative energy sources. Bamboo is a species of woody perennial grass that belongs to the Gramineae family and the Bambuseae subfamily. It could be considered a possible lignocellulosic substrate for the production of bioethanol due to its favourable environmental effects and increased yearly biomass yield.

Volar Barton Fracture and Ulnar Styloid Fracture With Distal Radial Ulnar Joint Disruption of the Right Wrist Without Neurovascular Deficit.

Volar Barton fracture is a common condition in dislocation of the distal radius of the volar or dorsal aspect. It occurs due to violent injury or road traffic accidents. Radius is one of the most common parts to get affected.

A Review of Physiotherapy Techniques Used in the Treatment of Tennis Elbow.

Tennis elbow, a common musculoskeletal disorder also known as lateral epicondylitis, causes pain and tenderness on the outside of the elbow. Although it is frequently linked to repetitive motions, such as those in racquet sports, it can affect people in a variety of occupations and activities. Tennis elbow can be treated conservatively with physiotherapy, which focuses on pain management, functional recovery, and recurrence prevention.

Waterpipe smoke inhalation induces lung injury and aortic endothelial dysfunction in mice.

Waterpipe tobacco smoking (WPS) inhalation has been shown to trigger endothelial dysfunction and atherosclerosis. However, the mechanisms underlying these effects are still unknown. Here, we assessed the impact and underlying mechanism of WPS exposure for one month on endothelial dysfunction using aortic tissue of mice.

The effect of different decontamination processes on the residues of fipronil and its metabolites in chili fruits (Capsicum annuum L.).

Fipronil is a broad-spectrum phenyl pyrazole insecticide that has a high degree of environmental toxicity. Commonly available chilies in the market are treated with fipronil insecticides. Demand for insecticide-free chili has thus been increasing globally.

Predictors of Non-Obstructive Coronary Artery Disease in Patients Undergoing Elective Coronary Angiography.

Background: Appropriate patient selection for coronary angiography (CAG) is essential to minimize the unnecessary risk of morbidities and exposure to radiation and iodinated contrast. This becomes even more relevant in low-to-middle-income settings where most health expenditures are out-of-pocket due to lack of medical insurance. We determined predictors of non-obstructive coronaries (NOC) in patients undergoing elective CAG.

Sentiment Analysis based Emotion Extraction for COVID-19 Using Crawled Tweets and Global Statistics for Mental Health.

The unpredictable and crucial challenges that occurred because of the COVID-19 pandemic disease have taken a gradual upsurge impacting over 213 countries across the globe. Different countries have taken several measures to get control over it like Lockdown, Curfews, Travel ban, etc. but still the cases were increasing and the situation was getting worse globally during some period of time.

Persistence and dissipation kinetics of novaluron 9.45% + lambda-cyhalothrin 1.9% ZC insecticides in tomato crop under semi-arid region.

In recent decades, fate studies of pesticides have been a topic of interest worldwide due to human health concerns tomato, contain abundant nutritional phytochemicals and lycopene which is known for antioxidant. Tomato is susceptible to many pest, so to overcome from these pests many insecticides are used, leaving residual effects on the crop. So to find out the persistence, the present study was carried out to investigate the residual levels and dissipation behaviour of novaluron 9.

Dissipation kinetics, risk assessment, and waiting period of spiromesifen on chili fruits using gas chromatography-electron capture detector.

A supervised field trial was designed in Rajasthan Agricultural Research Institute, Durgapura, Jaipur, Rajasthan, to assess the dissipation and persistence of spiromesifen in chili fruits. Spiromesifen (22.9% suspension concentrate) was sprayed two times at an interval of 10 days at the recommended dose (96 g.

An Edge-Supported Blockchain-Based Secure Authentication Method and a Cryptocurrency-Based Billing System for P2P Charging of Electric Vehicles.

The popularity of electric vehicles (EVs) is constantly increasing, as they use relatively greener, sustainable energy. However, it is a fact that the charging stations for EVs are yet to meet the demand. It could be a great solution if a peer-to-peer (P2P) charging system could be initiated by anyone who wants to make their garage's charge points publicly available for commercial purposes, named a home charging station (HCS).

Management and outcome of post-myocardial infarction ventricular septal rupture-A Low-Middle-Income Country Experience.

Background: Ventricular septal rupture (VSR) is a rare complication after acute myocardial infarction (AMI) especially in the reperfusion era but its associated mortality has remained high. This case series evaluated in-hospital and intermediate-term mortality in VSR patients. Additionally, we also analyzed risk factors, clinical presentation, intervention, and predictors of in-hospital mortality in VSR patients.

Patients' perception of personal protective equipment during the SARS-Cov-2 pandemic.

Background: Since the outbreak of the coronavirus (SARS-Cov-2), wearing personal protective equipment (PPE) has become necessary. Patients' ability to recognize staff is disrupted impacting on the relationship between healthcare worker and patient.

Objective: Assess the patients' perspective of healthcare workers wearing PPE and its effect on communication.

Synthesis, Molecular Modeling Study, and Quantum-Chemical-Based Investigations of Isoindoline-1,3-diones as Antimycobacterial Agents.

The condensation of phthalic anhydride afforded structurally modified isoindoline-1,3-dione derivatives with selected amino-containing compounds. The title compounds (-) have been characterized by thin-layer chromatography (TLC), infrared spectroscopy, H and C NMR spectroscopy, and mass spectroscopy. All of the compounds were assessed for their antimycobacterial activity toward the H37Rv strain by a dual read-out assay method.

AHP and TOPSIS based flood risk assessment- a case study of the Navsari City, Gujarat, India.

Flooding is one of the major natural catastrophic disasters that causes massive environmental and socioeconomic destruction. The magnitude of losses due to floods has prompted researchers to focus more on robust and comprehensive modeling approaches for alleviating flood damages. Recently developed multi-criteria decision making (MCDM) methods are being widely used to construct decision-making process more participatory, rational, and efficient.

Simultaneous determination of novel β-lactamase inhibitor WCK 4234 and Meropenem in dog plasma by LC-MS/MS and its application to preclinical pharmacokinetic study.

A precise and accurate liquid chromatography-tandem mass spectrometric (LC-MS/MS) bioanalytical method has been developed and validated for the simultaneous quantification of WCK 4234 and meropenem (MEM) in dog plasma. Protein precipitation using acetonitrile was employed as a sample preparation approach. Cefepime was used as an internal standard.