Popliteal endarterectomy for isolated popliteal arterial occlusive disease: A retrospective review study.

Objective: This study aims to assess the safety and viability of popliteal endarterectomy for isolated popliteal disease.

Method: The study is a retrospective review, single-institution review (2010-2020) which assessed all popliteal endarterectomies performed at a rural 180-bed teaching hospital. Cases were identified based on the CPT code.

Does Early Endoscopy Improve Mortality in Patients with Acute Non-variceal Gastrointestinal Bleeding? A Retrospective review.

Introduction Initial management of acute upper gastrointestinal bleeding (UGIB) aims towards aggressive fluid resuscitation to maintain hemodynamic stability. Existing evidence regarding the benefit of early endoscopy is unclear with some studies suggesting mortality benefits and some suggesting otherwise. The purpose of this study is to evaluate if there is any mortality benefit of doing early endoscopy within 24 hours of presentation.

Effect of median household income on surgical approach and survival in renal cell carcinoma.

Purpose: We sought to determine whether median household income (MHI) independently predicts surgical approach (partial vs. radical nephrectomy) and survival in patients with renal cell carcinoma.

Methods: The U.

Cutaneous schwannoma presenting as a lower back mass.

• Schwannomas are benign neoplasms composed of Schwann cells, that can arise anywhere in the body. • Schwannomas arise mainly in the dermal and subcutaneous tissue layers. • In this case report, we present a cutaneous schwannoma presenting as an enlarging left lower back solitary mass that was surgically excised.

Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes.

The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of p53 and a transmembrane-penetrating domain, has been found to kill cancer cells (but not normal cells) by inducing membranolysis. We find that our previously determined 3D structure of the p53 residues of PNC-27 is directly superimposable on the structure for the same residues bound to HDM-2, suggesting that the peptide may target HDM-2 in the membranes of cancer cells. We now find significant levels of HDM-2 in the membranes of a variety of cancer cells but not in the membranes of several untransformed cell lines.