The "20-minute Rule" in Lateral Lumbar Interbody Fusion. Fact or Fiction? A Multi-Center Analysis of 658 Patients.

Study DesignRetrospective Cohort Study.ObjectiveLateral lumbar interbody fusion (LLIF) is a treatment option for correcting lumbar degenerative pathologies that uses a retroperitoneal, transpsoas corridor to the disc space. Conventional teaching of the LLIF technique has been to perform the procedure 'as efficiently as possible', with a goal of keeping the total retractor time to less than 20 minutes to prevent injuries.

Factors associated with survival following allogeneic transplantation for myeloid neoplasms harboring TP53 mutations.

Allogeneic stem cell transplant (alloHCT) is considered for all patients with myeloid neoplasms (MN) harboring TP53-mutations (TP53mut). The aim of this international study across 7 transplant centers in USA and Australia was to identify factors associated with improved post-alloHCT survival. Of 134 TP53mut MN cases who underwent alloHCT, 80% harbored complex karyotype (CK); 94% of TP53 variants were localized to the DNA-binding domain (DBD).

Patient-Directed Discharge in Hand Infection Cases: Interactions Between Intravenous Drug Use, Socioeconomic Factors, and Subsequent Readmissions.

Background: Patient-directed discharge (PDD) poses a significant challenge in healthcare. Prior studies have shown associations of PDD with factors like race, housing, psychiatric illness, socioeconomic status, and intravenous drug use (IVDU). This study aims to identify factors contributing to PDD in hand infection patients at a public safety-net hospital and to investigate the long-term consequences through readmissions or returns to the emergency department (ED).

The role of F-fluorodeoxyglucose positron emission tomography/computed tomography-derived parameters as prognostic factors in patients undergoing resection for pancreatic ductal adenocarcinoma.

Background: The aim of this study is to investigate the role of maximum standardized uptake and tumor-to-liver ratio derived from preoperative F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with pancreatic ductal adenocarcinoma.

Methods: Patients who underwent pancreatic resection from January 2015 to December 2022 were reviewed. Patients were grouped based on disease-free survival of 1 year, disease-free survival of 6 months, overall survival of 1 year, and resectability.

The Natural History of Pediatric Cerebellopontine Angle Lipomas.

Objective: To present a series of pediatric patients with cerebellopontine angle (CPA) lipomas in order to understand their natural history and facilitate management recommendations.

Patients: Pediatric patients with a diagnosis of CPA lipoma.

Interventions: Clinical data collected from a single tertiary care center between January 2000 and August 2022.

Bioprospecting of cellulases from marine fungi for macro-algal biomass degradation for biofuel application.

The marine ecosystem, the largest on Earth, supports around 80 % of plant and animal species. Marine macroalgae, rich in polysaccharides like cellulose, remain underutilized despite their potential in a circular bioeconomy. Efficient valorization can promote sustainability, whereas mismanagement raises ecological concerns.

Gold nanoparticles-based targeted delivery of rapamycin and Olaparib to breast cancer: An in vitro and in vivo approach.

Triple negative form of breast cancer (abbreviated as TNBC) is considered as the most aggressive form causing high mortality worldwide. Different treatment modalities such as chemotherapy, surgery, hormonal therapy and radiation therapy are employed for eliminating breast cancer, which are associated with many limitations. Therefore, considering the significance of metal nanoparticles in the biomedical sector, especially gold nanoparticles, in the current manuscript, we have designed and developed a combinatorial approach for synthesizing two types of gold (Au) nanoformulations (Au-Dex-MUA-Rapa, Au-Dex-MUA-Ola) using 11-mercaptoundecanoic acid (MUA), dexamethasone (Dex) (glucocorticoid receptor targeted molecule) along with rapamycin (Rapa: inhibitor of mTOR) or olaparib (Ola: inhibitor of PARP) against TNBC.

Counterions influence the isothermal self-assembly of DNA nanostructures.

DNA nanostructures are typically assembled by thermal annealing in buffers containing magnesium. We demonstrate the assembly of DNA nanostructures at constant temperatures ranging from 4° to 50°C in solutions containing different counterions. The choice of counterions and the assembly temperature influence the isothermal assembly of several DNA motifs and designed three-dimensional DNA crystals.

Cutaneous lupus erythematosus presenting as a nonhealing ulcer in an African American woman: A case report.

Objective: Cutaneous lupus erythematosus (CLE) is a chronic autoimmune disorder of the skin.

Methods: In this report, we describe the case of an African American woman with CLE who had an ulcer on her posterior thigh. Despite this, initial biopsy specimen of the lesion revealed no evidence of CLE until a repeat biopsy 5 months later.

Plasma Cell-Rich Lymphoid Neoplasm in an Endocervical Polyp of the Uterine Cervix in a Perimenopausal 52-Year-Old Woman.

Background: The adaptive immune system consists of T and B lymphocytes, with some B lymphocytes further differentiating into plasma cells that secrete antibodies and make up the humoral immune system. Extramedullary plasmacytoma, mucosa-associated lymphoid tissue (MALT) lymphoma, and plasmablastic lymphoma are all plasma cell-rich lymphoid neoplasms that rarely present in the female genital tract. To date, few case reports of these malignancies arising within the uterine cervix exist.

Serum proteomics reveals high-affinity and convergent antibodies by tracking SARS-CoV-2 hybrid immunity to emerging variants of concern.

The rapid spread of SARS-CoV-2 and its continuing impact on human health has prompted the need for effective and rapid development of monoclonal antibody therapeutics. In this study, we investigate polyclonal antibodies in serum and B cells from the whole blood of three donors with SARS-CoV-2 immunity to find high-affinity anti-SARS-CoV-2 antibodies to escape variants. Serum IgG antibodies were selected by their affinity to the receptor-binding domain (RBD) and non-RBD sites on the spike protein of Omicron subvariant B.

Effects of Dopamine Agonists on the Estradiol-Induced Prolactin Surge in Ovariectomized Female Wistar Han Rats.

Dopamine agonists (DAs) are approved for the treatment of hypodopaminergic pathologies, including Parkinson's disease, restless legs syndrome, and periodic limb movement disorder. During drug development, drugs acting on dopaminergic receptors are often associated with a rat-specific endocrine tumor response, including changes in fertility, which are ascribed to DA-induced suppression of pituitary prolactin release. Although these effects are not observed in or relevant to humans, given species differences in the effects of prolactin on reproductive organs, modeling DA-mediated changes in prolactin and the reproductive system remains important for preclinical drug development.

Impact of Condoliase on Health-Related Quality of Life in Participants with Radicular Leg Pain Associated with Lumbar Disc Herniation: Results From a United States Phase 3 Clinical Trial.

Study Design: An exploratory analysis of a randomized, double-blind, sham-controlled, phase 3 study.

Objective: To evaluate the impact of SI-6603 (condoliase) on health-related quality of life (HRQoL)-related outcomes in patients with lumbar disc herniation (LDH)-associated radicular leg pain from the Discovery 6603 study (NCT03607838).

Summary Of Background Data: Condoliase is a novel chemonucleolytic agent that selectively degrades chondroitin sulfate in the nucleus pulposus.

Chronotype, sleep timing, sleep regularity, and cancer risk: A systematic review.

Sleep is a multidimensional modifiable lifestyle factor related to cancer risk. Prior research has primarily focused on sleep duration, despite the increasing importance of sleep timing and sleep regularity in the health research field. The objective of this systematic review was to synthesize the existing literature on the relationship of chronotype, sleep timing, and sleep regularity with cancer risk.

Comparative Analysis of Artificial Intelligence Platforms in Generating Post-Operative Instructions for Rhinologic Surgery.

Recently, artificial intelligence (AI) platforms such as ChatGPT and Google Gemini have progressed at a rapid pace. To allow for optimal medical outcomes and patient safety, it is crucial that patients have clearly written post-operative instructions. Patients are increasingly turning to AI platforms for medical information.

Impact of Concomitant Tonsillectomy on the Management and Outcomes of Pediatric Adenoidectomy.

Adenoidectomy is a common otolaryngologic procedure that may be performed with concomitant tonsillectomy (T&A). This study investigates differences between pediatric inpatients undergoing adenoidectomy alone and T&A. The 2016 Kid's Inpatient Database was used to identify pediatric patients undergoing adenoidectomy (ICD-10: 0CTQXZZ) with and without tonsillectomy (ICD-10: 0CTP, 0CBP).

Secondary SBP Prophylaxis is associated with a higher rate of non-SBP infections in Two US-based National Cirrhosis Cohorts.

Introduction: Antibiotic overuse and subsequent antibiotic resistance lead to worse infection outcomes in cirrhosis. Secondary spontaneous bacterial peritonitis prophylaxis (SecSBBPr) is associated with higher SBP recurrence but impact on non-SBP infections is unclear.

Methods: We studied patients with cirrhosis and SBP who were given SecSBPPr or not between 2009-2019 in two complementary national cohorts [Veterans affairs corporate data warehouse (VA-CDW) and non-VA TriNetX].

Bibliometrics and National Institutes of Health Funding: Associated Factors in Academic Rhinology.

Our study aims to evaluate demographics and research productivity in academic rhinology and to establish the relationship between bibliometrics such as the Hirsch index (-index) and the more recently developed relative citation ratio (RCR) and National Institutes of Health (NIH) funding. Retrospective cohort study. The demographics of academic rhinologists were collected from institutional faculty profiles ( = 207).

Evaluating the Effect of Video Source and Other Video Characteristics on the Quality, Reliability, Actionability, and Understandability of Videos on Acromioclavicular Joint Repair.

Purpose:  This study aims to evaluate video quality, reliability, actionability, and understandability differences based on length, popularity, and source credentials (physician versus non-physician). The hypothesis suggests that current videos are of low quality and limited usefulness to patients, highlighting significant disparities based on the credentials of the video source.

Methods:  The phrase "acromioclavicular joint separation" was searched on YouTube.

Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing noncardiac surgery: study protocol for a phase 2a, triple-blind, placebo-controlled randomised trial.

Background: Myocardial injury is strongly associated with excess morbidity and mortality after noncardiac surgery. Higher heart rate may result in perioperative myocardial injury through demand-supply mismatch. Alternatively, higher heart rates may reflect autonomic dysfunction that promotes myocardial injury independently of heart rate.

A humanized mouse model system mimics prenatal Zika infection and reveals premature differentiation of neural stem cells.

Zika, a mosquito-borne flavivirus, has been found in 87 countries and territories. Global outbreaks peaked in 2016. Prenatal infection of Zika virus was found to be associated with microcephaly, arthrogryposis, intracranial calcifications, fetal growth restriction, and fetal demise.

A propensity matched cohort analysis: Cemented vs press fit humeral stem fixation in anatomic total shoulder arthroplasty.

Introduction: Historically, humeral stems were cemented for anatomic shoulder arthroplasty (aTSA). However, cementless, or press-fit, fixation has been increasingly used. This study aims to compare outcomes and revision rates between cemented and press-fit humeral stems.

Leveraging Artificial Intelligence to Reduce Neuroscience ICU Length of Stay.

Goal: Efficient patient flow is critical at Tampa General Hospital (TGH), a large academic tertiary care center and safety net hospital with more than 50,000 discharges and 30,000 surgical procedures per year. TGH collaborated with GE HealthCare Command Center to build a command center (called CareComm) with real-time artificial intelligence (AI) applications, known as tiles, to dynamically streamline patient care operations and throughput. To facilitate patient flow for our neuroscience service line, we partnered with the GE HealthCare Command Center team to configure a Downgrade Readiness Tile (DRT) to expedite patient transfers out of the neuroscience intensive care unit (NSICU) and reduce their length of stay (LOS).

Real-World Effectiveness and Safety of Upadacitinib in Crohn's disease: A Multi-Centre Study.

Background: We aimed to describe the real-world effectiveness and safety of upadacitinib (UPA), an oral Janus kinase 1 inhibitor (JAKi) in patients with Crohn's disease (CD).

Methods: A retrospective analysis was conducted across nine centers in the United States, focusing on adults with CD treated with UPA 45 mg as induction therapy for active luminal disease. The co-primary endpoints were clinical remission at 12 weeks (Harvey Bradshaw Index ≤ 4 or absence of symptoms on physician's global assessment) and endoscopic remission at 6 months (SEMA-CD score of 0-1 or absence of ulcers).