Prenatal Sonographic Features of Noonan Syndrome: Case Series and Literature Review.

Noonan syndro me is a rare autosomal dominant congenital abnormality associated with a gene defect located on the short arm of chromosome 12. It is characterized by dysmorphic facies, webbed neck, short stature, lymphatic obstruction, cardiac anomalies, and intellectual disability. Prenatal diagnosis of Noonan syndrome is rare because there are no pathognomonic sonographic signs.

Nitric oxide donors for cervical ripening in first-trimester surgical abortion.

Background: Cervical priming before first-trimester surgical abortion is recommended in certain groups of women. Nitric oxide (NO) donors induce cervical ripening without uterine contractions, but the efficacy and side effects are of concern.

Objectives: To evaluate NO donors for cervical ripening before first-trimester surgical abortion, in terms of efficacy, side effects, and reduction of complications.

Intrauterine growth retardation fetus with trisomy 16 mosaicism.

Fetal trisomy 16 is considered uniformly lethal early in gestation. It has been reported to be associated with the variability of clinical features and outcomes. Mosaic trisomy 16 leads to a high risk of abnormality in prenatal cases.

Prenatal diagnosis and pathology of laryngeal atresia in congenital high airway obstruction syndrome.

Congenital high airway obstruction syndrome is a rare but life-threatening condition. Therefore, prenatal diagnosis is important. The obstruction can be due to laryngeal/tracheal atresia or external compression.

Nitric oxide donors for cervical ripening in first-trimester surgical abortion.

Background: Cervical priming before first-trimester surgical abortion is recommended in certain groups of women. Nitric oxide (NO) donors induce cervical ripening without uterine contractions, but the efficacy and side effects are of concern.

Objectives: To evaluate efficacy, side effects and complications of NO donors for cervical ripening before first-trimester surgical abortion.

Inhibin-A levels between 14 and 20 weeks of gestation in Thai women.

Aim: To construct a normal value for inhibin-A concentrations at 14-20 weeks of gestation for a Thai population.

Material And Methods: Inhibin-A concentrations from pregnant women without Down's syndrome at 14-20(+6) weeks of gestation were measured. Maternal serum inhibin-A levels were analyzed according to the gestational age.

Fetal loss associated with second trimester amniocentesis.

Objective: To evaluate the fetal loss rate associated with second trimester amniocentesis.

Methods: All cases of pregnant women ≥35 years old with gestational age beyond 16 weeks between 1997 and 2006 were included in this study. The study group consisted of all cases that the patients decided to have second trimester genetic amniocentesis.

Case report and review: prenatal diagnosis of congenital megalourethra.

Megalourethra is a rare congenital anomaly characterized by dilatation of the penile urethra which causes functional obstruction of the lower urinary system. We present a case of congenital megalourethra diagnosed prenatally. Transabdominal sonography revealed a male fetus with bilateral hydroureter, hydronephrosis, dilated bladder and normal amniotic fluid.

Effect of isosorbide mononitrate for cervical ripening before surgical termination of pregnancy in the first trimester.

Objective: To evaluate the efficacy of isosorbide mononitrate (IMN) for cervical ripening prior to first trimester surgical termination of pregnancy.

Methods: A prospective, double-blind, randomized, placebo-controlled trial. Women scheduled for surgical termination of a nonviable fetus before 12 weeks of gestation from October 2008 to June 2009 were enrolled and randomly assigned to receive either 20 mg vaginally of IMN (n=24) or a placebo (n=24) 4 hours before suction evacuation.

Nitric oxide donors for cervical ripening in first-trimester surgical abortion.

Background: Cervical priming before first-trimester surgical abortion is recommended in certain groups of women. Nitric oxide (NO) donors induce cervical ripening without uterine contractions, but the efficacy and side effects are of concern.

Objectives: To evaluate efficacy, side effects and complications of NO donors for cervical ripening before first-trimester surgical abortion.

Prenatal ultrasonographic findings in "trisomy 13".

Objective: To evaluate the accuracy of prenatal ultrasonographic diagnosis in fetuses with trisomy 13.

Material Method: The present study consisted of all fetuses diagnosed of trisomy 13 and delivered at Ramathibodi Hospital between 1997 and 2006.

Results: There were 15 cases of trisomy 13.

Trends of perinatal deaths at Ramathibodi Hospital: 1995-2005.

Objective: To study the trends in perinatal mortality rate and causes of perinatal deaths at Ramathibodi Hospital from 1995 to 2005.

Design: Retrospective descriptive study.

Material And Method: Review of medical records and reports during academic activities.