The utility of in-bore multiparametric magnetic resonance-guided biopsy in men with negative multiparametric magnetic resonance-ultrasound software-based fusion targeted biopsy.

Objectives: To evaluate the utility of in-bore multiparametric magnetic resonance-guided biopsy of the prostate (IB) in patients with visible lesion/s and previous negative software-based multiparametric magnetic resonance imaging/ultrasonography fusion-targeted biopsy of the prostate (FTB).

Patients And Methods: We retrospectively analysed prospectively maintained database including consecutive men undergoing IB from March 2013 to October 2017 in 2 European centres expert in this procedure. We selected men with the following criteria: No previous treatment for prostate cancer (CaP), multiparametric magnetic resonance imaging (mpMRI) lesion(s) PIRADS score ≥ 3, FTB showing no clinically significant cancer (csCaP), and subsequent IB.

Web-Based Communication of Socially Responsible Activities by Gambling Operators.

Application of the concept of corporate social responsibility (CSR) is of fundamental importance for the future existence and success of gambling operators, the activity of which is linked to a risk of addiction to gambling together with the negative impacts of this on the health and wellbeing of gamblers, families and society as a whole. Gambling operators must apply and effectively communicate socially responsible activities in the economic, environmental, ethical, social and philanthropic fields and in particular in the field of responsible gambling. Nowadays, it is necessary to ensure communication via modern channels in the form of corporate websites and social networks.

Problem-solving in caregiver-counselling (PLiP Study): study protocol of a cluster randomized pragmatic trial.

Background: Despite the positive evaluation of various caregiver interventions over the past 3 decades, only very few intervention protocols have been translated to delivery in service contexts. The purpose of this study is to train care counsellors of statutory long term care insurances in problem-solving and to evaluate this approach as an additional component in the statutory care counselling in Germany.

Methods: A pragmatic cluster randomized controlled trial in which 38 sites with 58 care counsellors are randomly assigned to provide either routine counselling plus additional problem-solving for caregivers or routine counselling alone.

Crohn's disease Activity: Abdominal Computed Tomography Histopathology Correlation.

Purpose: Crohn's disease is a type of inflammatory bowel disease affecting estimated 4 million people worldwide. Therapy stratification of Crohn's disease (CD) is mainly based on the inflammatory activity being assessed by endoscopic biopsy and clinical criteria. Cross-sectional imaging allows for the assessment of structural characteristics of the entire gastrointestinal tract including small bowel loops and may provide potential non-invasive image-based biomarkers for the inflammatory activity of CD.

Acute appendicitis in overweight patients: the role of preoperative imaging.

Background: The diagnosis of acute appendicitis in overweight patients is challenging due to the limited value of the clinical examination. The benefits of ultrasonography and abdominal CT have been studied in the general population, but there is limited data regarding their use in overweight and obese patients with suspected appendicitis. This study analyzes the role of preoperative radiological modalities in overweight patients with suspected appendicitis.

MR imaging features for improved diagnosis of hepatocellular carcinoma in the non-cirrhotic liver: Multi-center evaluation.

Purpose: To determine MR-imaging features for the differentiation between hepatocellular carcinoma (HCC) and benign hepatocellular tumors in the non-cirrhotic liver.

Material And Methods: 107 consecutive patients without liver cirrhosis (46 male; 45 ± 14 years) who underwent liver resection due to suspicion of HCC were included in this multi-center study. The following imaging features were assessed: lesion diameter and demarcation, satellite-lesions, central-scar, capsule, fat-content, hemorrhage, vein-infiltration and signal-intensity (SI) on native T1-, T2- and dynamic-enhanced T1-weighted images (center versus periphery).

Indications and selection of MR enterography vs. MR enteroclysis with emphasis on patients who need small bowel MRI and general anaesthesia: results of a survey.

Aims: To survey the perceived indications for magnetic resonance imaging of the small bowel (MRE) by experts, when MR enteroclysis (MREc) or MR enterography (MREg) may be chosen, and to determine how the approach to MRE is modified when general anaesthesia (GA) is required.

Materials And Methods: Selected opinion leaders in MRE completed a questionnaire that included clinical indications (MREg or MREc), specifics regarding administration of enteral contrast, and how the technique is altered to accommodate GA.

Results: Fourteen responded.

Automated small bowel motility measurements in MRI using 2D coronal slices - does the intrasegmental location matter? A pilot study.

Introduction: To evaluate if small bowel motility analyses are influenced by the positioning of the 2D-cross-section measurement point within the lumen.

Materials And Methods: Forty-four small-bowel motility measurements were included in this institutional review board-approved, prospective study. Motility sequences (Dixon-dynFFE; Temporal-resolution 1s, breath-hold) of the ileocecal region were acquired using magnetic resonance imaging (3.

Quantitative in vivo analysis of small bowel motility using MRI examinations in mice--proof of concept study.

Small bowel motility analyses using magnetic resonance imaging (MRI) could reduce current invasive techniques in animal studies and comply with the 'three Rs' rule for human animal experimentation. Thus we investigated the feasibility of in vivo small bowel motility analyses in mice using dynamic MRI acquisitions. All experimental procedures were approved by the institutional animal care committee.

Teachers or psychologists: who should facilitate depression prevention programs in schools?

The current study evaluates a depression prevention program for adolescents led by psychologists vs. teachers in comparison to a control. The universal school-based prevention program has shown its efficacy in several studies when implemented by psychologists.

MRI for characterization of primary tumors in the non-cirrhotic liver: added value of Gd-EOB-DTPA enhanced hepatospecific phase.

Purpose: To evaluate the added value of hepatospecific phase in Gd-EOB-DTPA enhanced magnetic resonance imaging (MRI) in patients with primary tumors in non-cirrhotic liver.

Methods: Twenty-nine patients (median, 39 years; range, 18-81 years; 11 male) underwent preoperative Gd-EOB-DTPA enhanced MRI including hepatospecific phase after 10 and 20 min of contrast injection at four institutions in Europe, North America and New Zealand. Images were evaluated by three different readers (R1-R3) who characterized liver tumors with and without consultation of the hepatospecific phase images.

Correlation between morphological expansion and impairment of intra- and prelesionary motility in inflammatory small bowel lesions in patients with Crohn's disease - preliminary data.

Introduction: The aim of this study is to investigate if alterations of intra- and prelesionary motility in inflamed small-bowel segments correlate with length, wall-thickness and prelesionary dilatation of inflammatory small bowel lesions in patients suffering from Crohn's disease assessed with MRI.

Methods And Materials: This retrospective IRB approved study included 25 patients (12 males, 18-77y) with inflammatory lesions examined using (MRE) magnetic resonance imaging enterography. Cine MRE was performed using a coronal 2D steady-state free precession sequence (TR 2.

Managing multicentre clinical trials with open source.

Background: Multicentre clinical trials are challenged by high administrative burden, data management pitfalls and costs. This leads to a reduced enthusiasm and commitment of the physicians involved and thus to a reluctance in conducting multicentre clinical trials.

Objective: The purpose of this study was to develop a web-based open source platform to support a multi-centre clinical trial.

Software-assisted quantitative analysis of small bowel motility compared to manual measurements.

Aim: To validate a newly developed software prototype that automatically analyses small bowel motility by comparing it directly with manual measurement.

Material And Methods: Forty-five patients with clinical indication for small bowel magnetic resonance imaging (MRI) were retrospectively included in this institutional review board-approved study. MRI was performed using a 1.

Small-bowel dislocation during long-term MRI observation - insights in intestinal physiology.

Magnetic resonance imaging (MRI) of the abdomen is a widely established imaging modality in the diagnostic workup of patients suffering from abdominal disorders. Small-bowel motility analyses using MRI have recently been introduced to provide functional information about the intestine not provided by morphological analyses. This is of clinical importance as motility disorders correlate with inflammation.

Liver unidentified bright object in a septic patient.

The typical sonographic appearance of liver hemangiomas is a well-demarcated hyperechoic mass with homogeneous echodensity. Focal liver lesions may change their ultrasound characteristics over time. We present a case of dynamic pattern of liver hemangiomas during a state of systemic inflammation.

Software-supported evaluation of gastric motility in MRI: a feasibility study.

Introduction: The aim of this study was to evaluate the feasibility of dedicated motility assessment software for quantitative evaluation of basic gastric motility and to validate it using manual measurements.

Methods: Ten patients (5 males/5 females, mean 41 years) out of a previous series of small bowel MR-enterography examinations with well visible stomachs were included in this Institutional Reviews Board approved, retrospective study. MRI (1.

Differentiation between active and chronic Crohn's disease using MRI small-bowel motility examinations - initial experience.

Aim: To evaluate the influence of locally active Crohn's disease on systemic small-bowel motility in patients with chronic Crohn's disease compared to healthy individuals.

Material And Methods: Fifteen healthy individuals (11 men, four women; mean age 37 years) and 20 patients with histopathologically proven active (n = 15; 10 women, 5 men; mean age 45 years) or chronic (n = 5; four women, one man; mean age 48 years) Crohn's disease were included in this institutional review board-approved, retrospective study. Magnetic resonance imaging (MRI; 1.

Gadoxetate uptake as a possible marker of hepatocyte damage after liver resection-preliminary data.

Aim: To determine the feasibility of evaluating surgically induced hepatocyte damage using gadoxetate disodium (Gd-EOB-DTPA) as a marker for viable hepatocytes at magnetic resonance imaging (MRI) after liver resection.

Material And Methods: Fifteen patients were prospectively enrolled in this institutional review board-approved study prior to elective liver resection after informed consent. Three Tesla MRI was performed 3-7 days after surgery.

[School Based, Universal Primary Prevention of Depressive Symptoms (Disorders) in Adolescents].

The universal prevention programme "Lifeskills with LARS&LISA" includes 10 sessions held in a regular school setting. We expected the programme to empower young people to improve their life skills, to foster their realistic thinking, to influence school behaviour and thus to prevent the development of depressive symptoms. The "Lifeskills with LARS&LISA" programme can be successfully delivered to a school-based population (grades 7-8) and integrated into the classroom curriculum.

MR imaging in Crohn's disease: correlation of MR motility measurement with histopathology in the terminal ileum.

Background: The objective of the study was to correlate MR-detectable motility alterations of the terminal ileum with biopsy-documented active and chronic changes in Crohn's disease.

Methods: This IRB approved retrospective analysis of 43 patients included magnetic resonance enterography (MRE) and terminal ileum biopsies (<2 weeks apart). Motility was measured at the terminal ileum using coronal 2D trueFISP pulse sequences (1.

Software-assisted small bowel motility analysis using free-breathing MRI: feasibility study.

Purpose: To validate a software prototype allowing for small bowel motility analysis in free breathing by comparing it to manual measurements.

Materials And Methods: In all, 25 patients (15 male, 10 female; mean age 39 years) were included in this Institutional Review Board-approved, retrospective study. Magnetic resonance imaging (MRI) was performed on a 1.

Crohn's disease: small bowel motility impairment correlates with inflammatory-related markers C-reactive protein and calprotectin.

Background: To evaluate the correlation between the levels of C-reactive protein (CRP), calprotectin, and small bowel motility in patients with Crohn's disease assessed with MRI.

Methods: This prospective institutional review board approved study included magnetic resonance imaging enterography (MRE) and analyses of inflammatory markers in blood (C-reactive protein) and feces (calprotectin). For cine MRE, a coronal 2D-T2w sequence was used on a 1.

Automatic detection of small bowel contraction frequencies in motility plots using lomb-scargle periodogram and sinus-fitting method--initial experience.

Purpose: Contraction frequencies are an important parameter for the analysis of bowel motility in MRI. The contraction curve can be rather noisy and the frequency-evaluation might be difficult. The aim was to evaluate manual calculations of small bowel contraction frequency in comparison with automatic calculations using two mathematically established methods.