Antimicrobial Susceptibility of and spp. Isolates From Healthy Pigs in Australia: Results of a Pilot National Survey.

This study investigated the frequency of antimicrobial non-susceptibility (defined as the frequency of isolates with minimum inhibitory concentrations above the CLSI susceptible clinical breakpoint) among and spp. isolated from healthy Australian finisher pigs. ( = 201) and spp.

Decision-making in early clinical drug development.

This paper illustrates an approach to setting the decision framework for a study in early clinical drug development. It shows how the criteria for a go and a stop decision are calculated based on pre-specified target and lower reference values. The framework can lead to a three-outcome approach by including a consider zone; this could enable smaller studies to be performed in early development, with other information either external to or within the study used to reach a go or stop decision.

Pharmacokinetic and pharmacodynamic profile of rosuvastatin in patients with end-stage renal disease on chronic haemodialysis.

Background: Rosuvastatin has been shown to provide effective treatment of dyslipidaemia in patients with end-stage renal disease (ESRD) undergoing haemodialysis, but data from controlled trials are very limited on the pharmacokinetics and pharmacodynamics of rosuvastatin in this population.

Objective: The aim of the present study was to better define the pharmacokinetic and pharmacodynamic profiles of repeated doses of rosuvastatin at a starting dose of 10 mg/day in a group of patients with ESRD.

Study Design: This was a single-centre, open-label study of rosuvastatin 10 mg daily, given over a 16-day treatment period in patients with ESRD undergoing chronic haemodialysis.

Cultural barriers to exclusive breastfeeding by mothers in a rural area of Cameroon, Africa.

Because of the known nutritional and health benefits to the infant, the World Health Organization recommends that women in resource-poor countries exclusively breastfeed until their babies reach 6 months of age. In the primarily rural geographical region of the North West Province of Cameroon, previous studies identified the prevalence of breastfeeding to be 90%. It is common knowledge that women are culturally encouraged to mix-feed their infants, but the extent of these feeding practices is not known.

Joint replacement and case management in indigent hospitalized patients.

More than 260,000 total joint replacements are performed every year in the United States. The University of New Mexico Hospital is a publicly held hospital that provides healthcare to many patients who are uninsured and indigent. More than 200 joint replacement surgeries are performed every year at University Hospital, Albuquerque, NM, resulting in an average length of stay of 5.

Procedure for the assessment of lung function with spirometry.

Spirometry records breath movements, inhalation and exhalation, and is integral to the management of lung disease, alongside good history taking and careful documentation. Tests can indicate a patient's optimal response to treatment or triggers, and the rate of decline in lung function. It is useful to detect the presence of lung disease, those susceptible to developing lung disease and to classify patients into severity classifications to optimise management.