Drug repositioning and repurposing for Alzheimer disease.

Drug repositioning and repurposing can enhance traditional drug development efforts and could accelerate the identification of new treatments for individuals with Alzheimer disease (AD) dementia and mild cognitive impairment. Transcriptional profiling offers a new and highly efficient approach to the identification of novel candidates for repositioning and repurposing. In the future, novel AD transcriptional signatures from cells isolated at early stages of disease, or from human neurons or microglia that carry mutations that increase the risk of AD, might be used as probes to identify additional candidate drugs.

Aspiration of an avulsed primary incisor: a case report.

This case report describes a 7-year-old boy who avulsed and inhaled a primary maxillary incisor. Over the next number of weeks, he developed a persistent, productive cough, which was unresponsive to antibiotic therapy. Radiographic examination revealed a small radiopaque tooth-shaped object in the right hilar lung region.