Publications by authors named "Pasumpon Kamaraj"
Article Synopsis
- A scalable synthesis process for the preclinical drug candidate DNDI-VL-2098, aimed at treating visceral leishmaniasis, is outlined.
- The synthesis involves a four-step method, including the Sharpless asymmetric epoxidation of 2-methyl-2-propen-1-ol and utilizes retrosynthetic analysis to optimize the route.
- The process is streamlined by using in situ synthesis for intermediates, which enhances safety and eliminates the need for column chromatography, resulting in high yields and purity on a kilogram scale.
Design and synthesis of a novel tetraphenylethene-2-pyrone (TPEP) conjugate exhibiting donor-acceptor characteristics is reported. The localized frontier molecular orbitals (DFT studies) and the solvent polarity dependent photoluminescence characteristics directly corroborate the presence of intramolecular charge transfer character in TPEP. TPEP is poorly emissive in the solution state.
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