Primary prophylaxis for Pneumocystis jirovecii pneumonia in patients with connective tissue diseases.

Objectives: The aim of our study was to examine the primary prophylactic effect of sulfamethoxazole/trimethoprim single strength (SMZ/TM SS) against Pneumocystis jirovecii pneumonia (PCP) in connective tissue disease (CTD) patients with immune dysfunction induced by the long-term use of prednisolone. Prevalence of adverse drug reactions (ADRs) to sulfonamide in these patients was the secondary outcome.

Methods: This was a retrospective cohort study.