Prognostic factors and impact of management strategies for status epilepticus: The STEPPER study in the Emilia-Romagna region, Italy.

Objective: The STEPPER (Status Epilepticus in Emilia-Romagna) study aimed to investigate the clinical characteristics, prognostic factors, and treatment approaches of status epilepticus (SE) in adults of the Emilia-Romagna region (ERR), Northern Italy.

Methods: STEPPER, an observational, prospective, multicentric cohort study, was conducted across neurology units, emergency departments, and intensive care units of the ERR over 24 months (October 2019-October 2021), encompassing incident cases of SE. Patients were followed up for 30 days.

Effects of β-Glucan Supplementation on LPS-Induced Endotoxemia in Horses.

β-glucan is part of the cell wall of fungi and yeasts and has been known for decades to have immunomodulating effects on boosting immunity against various infections as a pathogen-associated molecular pattern that is able to modify biological responses. β-glucan has been used in rat models and in vitro studies involving sepsis and SIRS with good results, but this supplement has not been evaluated in the treatment of endotoxemia in horses. This study aims to evaluate the effects of preventive supplementation with β-glucan in horses submitted to endotoxemia by means of inflammatory response modulation.

Complications following transcutaneous cecal trocarization in horses with a cattle trocar and a cecal needle.

Percutaneous decompression of the cecum is a procedure that could be considered for horses with cecal gas distension. The aim of this study was to identify complications such as peritonitis and clinically relevant peritonitis (CRP) after transabdominal cecal trocarization in healthy horses using a cattle trocar and a cecal needle. Mixed breed horses were assigned to three groups (n = 6): horses that underwent trocarization with a cecal needle (G1) or a cattle trocar (G2), and a control group (CG) without cecal trocarization.

Augmenting salivation, but not evaluations, through subliminal conditioning of eating-related words.

Correlating eating-related words (CS) with positively valenced words (US+) may augment eating-associated motivational responses (e.g., preingestive salivation) with minimal CS knowledge.

Exploring a Training IRAP as a single participant context for analyzing reversed derived relations and persistent rule-following.

Rule-governed behavior and derived stimulus relations have always shared strong conceptual links within behavior analysis. However, experimental analysis linking the two domains remains limited. The current study consisted of three experiments that aimed to continue to bridge this experimental gap.

Dissociating preferences from evaluations following subliminal conditioning.

Preferences towards unfamiliar drink brands may be influenced through subliminal conditioning. This can involve associating unfamiliar brands (CS) with positively valenced attributes (US) under constrained visual conditions to prevent the former's conscious detection. According to learning theory, CS associated with positive US should become increasingly preferred as the latter's positive valences generalizes (transfer) across associated CS.

Corrigendum: Effects of Nodal Distance on Conditioned Stimulus Valences Across Time.

[This corrects the article DOI: 10.3389/fpsyg.2019.

Effects of Nodal Distance on Conditioned Stimulus Valences Across Time.

A meaningless symbol that repeatedly co-occurs with emotionally salient faces (US) can transform into a valenced symbol (CS). US-to-CS valence transformations have been observed for CS that have been directly (US→CS0) and indirectly (US→CS0→CS1→CS2) linked with face US. The structure of a US→CS0→CS1→CS2 series may be conceptualized in terms of "nodal distance," where CS0, CS1, and CS2 are 0, 1, and 2 nodes from the US respectively.

Congenital Transmission of After Experimental Reinfection With Brazilian Typical Strains in Chronically Infected Sheep.

is a cause of congenital diseases, miscarriages and stillbirths in production animals. In Brazil, non-archetypal genotypes of the parasite may be related to severe disease. Experimental infection with was studied in sheep to analyse congenital transmission-related parameters in reinfections with different Brazilian parasite strains.

Effects of orientation and differential reinforcement II: transitivity and transfer across five-member sets.

A recent report by Amd et al. (2017) demonstrated that orienting towards successively presented stimulus-stimulus pairs yielded significantly more transitive relations then when those same pairs were differentially reinforced following training for three, 3-member stimulus sets. We build on that work in four important ways.

Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy.

Objective: Autosomal-dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy characterized by auditory symptoms. Two genes, LGI1 and RELN, encoding secreted proteins, are implicated in the etiology of ADLTE, but half of the affected families remain genetically unsolved, and the underlying molecular mechanisms are yet to be clarified. We aimed to identify additional genes causing ADLTE to better understand the genetic basis and molecular pathway underlying this epileptic disorder.

Transplantation of amniotic membrane-derived multipotent cells ameliorates and delays the progression of chronic kidney disease in cats.

Chronic kidney disease (CKD) is a common clinical condition in domestic cats, characterized by tubulointerstitial, vascular and glomerular inflammation and severe fibrosis. Studies in rodent model of induced CKD have shown a decrease and stabilization of the clinical condition. In this study was evaluated the safety and effect of intrarenal and intravenous infusion of allogeneic mesenchymal stem cells (AMSCs) derived from feline amniotic membrane in cats with naturally occurring CKD.

Controversial results of therapy with mesenchymal stem cells in the acute phase of canine distemper disease.

Distemper disease is an infectious disease reported in several species of domestic and wild carnivores. The high mortality rate of animals infected with canine distemper virus (CDV) treated with currently available therapies has driven the study of new efficacious treatments. Mesenchymal stem cell (MSC)-based therapy is a promising therapeutic option for many degenerative, hereditary, and inflammatory diseases.

Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef cattle.

Background: The selection of beef cattle for feed efficiency (FE) traits is very important not only for productive and economic efficiency but also for reduced environmental impact of livestock. Considering that FE is multifactorial and expensive to measure, the aim of this study was to identify biological functions and regulatory genes associated with this phenotype.

Results: Eight genes were differentially expressed between high and low feed efficient animals (HFE and LFE, respectively).

Familial epilepsy and developmental dysphasia: description of an Italian pedigree with autosomal dominant inheritance and screening of candidate loci.

Purpose: To describe a familial epileptic condition combining a peculiar electro-clinical pattern with developmental language dysfunction in a large Italian kindred.

Methods: We studied the clinical and neurophysiological features of a 4-generation family with 10 affected members (3 deceased). We also analysed in 7 affected and 7 healthy members microsatellite markers for 51 candidate loci for epilepsy, including 42 loci containing ion channel genes expressed in the brain, as well as the SPCH1 and SRPX2 loci.

Evaluation of the adverse effects of subcutaneous carprofen over six days in healthy cats.

This study evaluated the adverse effects of carprofen in seven healthy cats. Values for CBC, biochemical profiles and platelet aggregation were measured before and at seven days after SID treatment with subcutaneous carprofen: 4 mg/kg (day 1), 2mg/kg (day 2 and 3) and 1mg/kg (day 4 and 6) (CG) or 0.35 ml of saline (SG) for six days in a randomized, blinded, cross-over study with a four-week washout period.

Familial mesial temporal lobe epilepsy (FMTLE) : a clinical and genetic study of 15 Italian families.

Introduction: Familial mesial temporal lobe epilepsy (FMTLE) is characterized by prominent psychic and autonomic seizures, often without hippocampal sclerosis (HS) or a previous history of febrile seizures (FS), and good prognosis. The genetics of this condition is largely unknown.We present the electroclinical and genetic findings of 15 MTLE Italian families.

Autosomal dominant lateral temporal epilepsy: clinical spectrum, new epitempin mutations, and genetic heterogeneity in seven European families.

Purpose: [corrected] To describe the clinical and genetic findings of seven additional pedigrees with autosomal dominant lateral temporal epilepsy (ADLTE).

Methods: A personal and family history was obtained from each affected and unaffected member, along with a physical and neurologic examination. Routine and sleep EEGs, computed tomography (CT), or magnetic resonance imaging (MRI) were performed in almost all the patients.

Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy.

Autosomal dominant lateral temporal epilepsy (EPT; OMIM 600512) is a form of epilepsy characterized by partial seizures, usually preceded by auditory signs. The gene for this disorder has been mapped by linkage studies to chromosomal region 10q24. Here we show that mutations in the LGI1 gene segregate with EPT in two families affected by this disorder.

Autosomal dominant partial epilepsy with auditory features: description of a new family.

Purpose: To report the clinical and genetic study of a new family with autosomal dominant partial epilepsy with auditory features (ADPEAF).

Methods: All the living affected members underwent a full clinical, neurophysiological, and magnetic resonance imaging (MRI) study. Genetic analysis was performed by typing their DNA with seven microsatellite markers previously found to cosegregate with ADPEAF on chromosome 10q24.

Electroclinical features of idiopathic generalised epilepsy with persisting absences in adult life.

Objectives: To describe the electroclinical features of typical absences persisting in adult life.

Methods: Twelve adult patients (aged 21 to 56 years) with idiopathic generalised epilepsy featuring typical absences as the prominent clinical feature were studied. All patients underwent a full clinical and neurophysiological investigation including ictal documentation of seizures.

Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy.

Purpose: To assess whether phenytoin affects the pharmacokinetics of the dihydropyridine calcium antagonist nisoldipine.

Methods: Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively). Blood samples were collected for up to 48 h for estimation of plasma nisoldipine levels by capillary gas chromatography.