Publications by authors named "Pasquier M"
Article Synopsis
- The Avalanche Victim Resuscitation Checklist (AVRC) was created to enhance the management of avalanche victims experiencing cardiac arrest, as prior compliance with international guidelines was poor.
- A study over ten years examined the effectiveness of the AVRC, revealing significant improvements in guideline compliance (from 59% to 95%) and complete documentation after its implementation.
- The findings suggest that while the AVRC enhances patient management for critically buried victims, further quality improvements are needed for those buried for extended periods.
DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns in vertebrates. Here we structurally and biochemically explore the interaction of DNMT3A1 with diverse modified nucleosomes indicative of different chromatin environments. A cryo-EM structure of the full-length DNMT3A1-DNMT3L complex with a H2AK119ub nucleosome reveals that the DNMT3A1 ubiquitin-dependent recruitment (UDR) motif interacts specifically with H2AK119ub and makes extensive contacts with the core nucleosome histone surface.
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- The study examines critically buried avalanche victims with cardiac arrest, emphasizing that a noncompressible chest wall or frozen body usually prevents CPR initiation, though the supporting evidence is weak.
- A retrospective analysis of 53 avalanche victims declared dead from 2010-2019 revealed that 23% had noncompressible chest walls, which were linked to longer burial times and lower body temperatures.
- The findings suggest that the presence of a noncompressible chest wall alone is not enough to confirm death in these cases and that more clinical information is needed for accurate assessments.
Objectives: To conduct a systematic literature search to identify currently used classifications of acute non-contact muscle injuries in sporting adults.
Designs: Scoping review.
Methods: A systematic literature search from January 1, 2010 to April 19, 2022 of Medline and SPORTDiscus yielded 13,426 articles that were screened for eligibility.
Background: Tranexamic acid (TXA) decreases mortality in injured patients and should be administered as soon as possible. Despite international guidelines recommending TXA in the prehospital setting, its use remains low. The aim of this study was to assess the prehospital administration of TXA for injured patients in a Swiss region.
View Article and Find Full Text PDFThe HOPE score (https://www.hypothermiascore.org) is a validated instrument for estimating the survival probability of patients in hypothermic cardiac arrest with ECLS rewarming.
View Article and Find Full Text PDFObjective: We aimed to determine the feasibility of quality indicators (QIs) for prehospital advanced airway management (PAAM) from a provider point of view.
Design: The study is a survey based feasibility assessment following field testing of QIs for PAAM.
Setting: The study was performed in two physician staffed emergency medical services in Switzerland.
Article Synopsis
- Suspension syndrome occurs when a person experiences cardio-circulatory collapse while hanging vertically, with ongoing debate about its causes.
- A scoping review by ICAR MedCom analyzed various studies to clarify the syndrome's pathophysiology and provide updated recommendations for its management.
- The findings suggest that suspension syndrome can lead to serious complications, including bradycardia and loss of consciousness, and emphasize the importance of prevention strategies and quick medical intervention in case of an emergency.
Eelgrass supports diverse benthic communities that ensure a variety of ecosystem functions. To better understand the ecological processes that shape community composition in eelgrass at local and regional scales, taxonomic and functional α- and β-diversity were quantified for communities inhabiting five meadows in France. The extent to which environmental factors affected local and regional benthic communities was quantified by considering their direct and indirect effects (through morphological traits of eelgrass) using piecewise structural equation modeling (pSEM).
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- - Spinal mobilization (SMob) is a common treatment for spinal pain, but previous studies have issues with clarity in their methods, making it hard to interpret results.
- - This study reviewed literature from various databases to analyze the characteristics of SMob, focusing on force-time metrics, the types of participants involved, and the regions of the spine being treated.
- - Out of 7,607 records, 36 studies were included, showing that most SMob treatments targeted the lumbar and cervical spines; results indicated a wide range of force and duration used in these treatments, highlighting inconsistencies that future research should address.
Article Synopsis
- Spinal manipulation (SM) is an effective treatment for musculoskeletal disorders, and understanding its kinetic parameters (like force application and thrust duration) can help identify what makes it clinically effective.
- This study conducted a scoping literature review, analyzing relevant studies to synthesize existing data on force-time characteristics of SM, utilizing databases like MEDLINE and Embase up until October 2022.
- Out of 7,607 records reviewed, only 66 studies met the criteria for analysis, revealing variations in the spinal regions treated (cervical, thoracic, lumbopelvic) and emphasizing the need for clearer data on SM's force-time characteristics.
Background: The purpose of this study was to investigate how feedback and self-assessment strategies affect performance and retention of manual skills in a group of chiropractic students.
Methods: Seventy-five students participated in two spinal manipulation (SM) learning sessions using a force-sensing table. They were recruited between May and November 2022 during HVLA technical courses.
Background: Patients with severe pelvic fractures carry a greater risk of severe bleeding, and pelvic compression devices (PCCD) are used to stabilize the pelvis on the pre-hospital scene. The aim of this study was to describe the use of PCCD in the pre-hospital setting on a nationwide scale (Switzerland) and determine the sensitivity, specificity and rates of over- and under-triage of the current application practices. The secondary objective was to identify pre-hospital factors associated with unstable pelvic fractures.
View Article and Find Full Text PDFAims: Our goal was to study hypothermic cardiac arrest (CA) patients who were not rewarmed by Extracorporeal Life Support (ECLS) but were admitted to a hospital equipped for it. The focus was on whether the decisions of non-rewarming, meaning termination of resuscitation, were compliant with international guidelines based on serum potassium at hospital admission.
Methods: We retrospectively included all hypothermic CA who were not rewarmed, from three Swiss centers between 1st January 2000 and 2nd May 2021.
Article Synopsis
- Takotsubo cardiomyopathy is a heart condition that can be triggered by extreme stress, often presenting as temporary left ventricular dysfunction.
- This case study details a 41-year-old woman who experienced mid-ventricular Takotsubo cardiomyopathy after being completely buried in an avalanche for 30 minutes, leading to hypothermia and heart rhythm issues.
- After treatment and recovery, both her heart function and psychological condition improved significantly, highlighting the impact of physical and emotional stress combined with hypothermia on heart health.
Low back pain ranks as the leading cause of years lived with disability worldwide. Although best practice guidelines share a consistent diagnostic approach for the evaluation of patients with low back pain, confusion remains as to what extent patient history and physical examination findings can inform management strategies. The aim of this study was to summarize evidence investigating the diagnostic value of patient evaluation components applicable in primary care settings for the diagnosis of low back pain.
View Article and Find Full Text PDFStudy Question: Is the total number of oocytes retrieved with dual ovarian stimulation in the same cycle (duostim) higher than with two consecutive antagonist cycles in poor responders?
Summary Answer: Based on the number of total and mature oocytes retrieved in women with poor ovarian response (POR), there is no benefit of duostim versus two consecutive antagonist cycles.
What Is Known Already: Recent studies have shown the ability to obtain oocytes with equivalent quality from the follicular and the luteal phase, and a higher number of oocytes within one cycle when using duostim. If during follicular stimulation smaller follicles are sensitized and recruited, this may increase the number of follicles selected in the consecutive luteal phase stimulation, as shown in non-randomized controlled trials (RCT).