PATHOGENETIC LINKS OF THE COMBINED COURSE OF CHRONIC PANCREATITIS AND HYPERTENSIVE DISEASE AND THEIR ROLE IN THE FORMATION OF COMPLICATIONS.

Objective the purpose of the study the relationship between the gene polymorphism of vitamin D receptors (VDR) and biochemical markers of bone metabolism in the risk of osteoporosis in patients with chronic pancreatitis (CP) and hypertensive disease (HD). 110 patients with CP were examined, in which it proceeded against the background of HD in 70 cases, and in 40 cases it was isolated. The polymorphism of the VDR gene, the content of osteocalcin, total acid phosphatase (TAP), and tartrate-resistant acid phosphatase (TRAP) were studied to determine the possible effect of these parameters on the course of the disease and the formation of complications.

[Role of environmental factors in patients with circulatory disturbance syndrome who developed low-dose radiation-induced peptic ulcer].

98 patients actually in the zone of abnormal radiation developed peptic ulcer with its characteristic clinical manifestations as evidenced by a morphological study of the mucus and values for gastric secretion. The findings secured are considered to be a manifestation of parasympaticotonia-related discirculatory syndrome, which fact warrants institution of a corrective therapy.

[The correction of free-radical oxidation processes in patients with chronic cholecystitis subjected to ionizing radiation exposure].

An activation was found of lipid peroxidation system as well as suppression of antioxidant defence tending to be more profound in blood erythrocytes, in 47 patients with chronic cholecystitis having been in the zone of abnormal radiation. Correction of the above alterations revealed unithiol, clinical and biochemical effects to be pronounced compare with those or tocopherol. Direct antioxidant effect or unithiol, its capability of serving as an antidote of heavy of heavy metals are believed to account for the above observation.

[Lipid peroxidation and the antioxidant system in chronic cholecystitis in persons located in an area of increased radiation].

The studies covered 35 subjects with chronic cholecystitis who had to work in radionuclide-contaminated territory. There appeared changes in examinees' lipid peroxidation and antioxidant defense systems. These were more pronounced in leukocytes, possibly due to direct action of radiation on cell membrane, and may contribute to disease chronicity and recurrences.

[Body reactivity and lipid peroxidation in patients with chronic gastroduodenitis living in an area of elevated ionizing radiation].

Reactivity of organism was studied in a total of 48 patients with chronic duodenitis, actually in the zone of increased radiation. Hypo- and normotensive type reactions were found to prevail, each having its peculiar clinical picture. While studying the lipid peroxidation- and antioxidant defence systems, changes were identified in those parameters characterizing the above systems, their degree being higher in blood leukocytes.

[The prevalence, risk factors and secondary prevention of digestive tract diseases in workers of the gas-producing industry].

The examination of the Ukrburgas corporation employees revealed gastrointestinal diseases in 107 of them (18.4%): ulcer in 28 and chronic gastroduodenitis in 79 subjects. The above disorders proved dependent on occupational, social and risk factors.

[The pharmacological correction of reflex stenocardia due to chronic noncalculous cholecystitis].

Results are reported of a study of the effect of benzohexonium electrophoresis on the epigastric area in cardiac syndrome due to chronic noncalculous cholecystitis in 72 patients. This treatment produced a favourable effect in reflex stenocardia as confirmed by data of clinical and paraclinical findings. The authors recommended to include benzohexonium electrophoresis in patients with the biliary cardiac syndrome in the complex treatment of patients with chronic cholecystitis.

[The prevalence and secondary prevention of ischemic heart disease and arterial hypertension in workers of the gas recovery industry].

Results are reported of the incidence of ischemic heart disease and arterial hypertension in workers of the gas producing industry. There was a direct correlative dependence on age, profession, character of work. Schemes are presented on the treatment with consideration of the course of the disease.