The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood.

Objective: The Pro12Ala polymorphism in exon B of peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) gene has been related to obesity, insulin resistance, and risk of type 2 diabetes. In this study, the effect of the Pro12Ala polymorphism on long-term changes in weight and body composition was investigated.

Research Methods And Procedures: The Pro12Ala polymorphism was genotyped in 311 subjects who participated in our previous population-based study.