Povidone-iodine functionalized nanofibers are prophylactic and protect against dissemination of SARS-CoV-2 infection.

The novel personal protection equipment based on a face mask equipped with a nanofiber filter functionalized with povidone iodine has been developed and tested in a clinical trial. This nanofiber filter was characterized with a low flow resistance and, thus, allowed comfortable breathing. The performed study proved that the novel nanofiber filter with incorporated povidone-iodine was characterized with a slow release of iodine which minimized side effects but kept disinfection efficiency.

Electrospun Nanofibers Encapsulated with Natural Products: A Novel Strategy to Counteract Skin Aging.

The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines nanotechnology and traditional treatments to create innovative drugs.

Hydrolat of Helichrysum italicum promotes tissue regeneration during wound healing.

Wound healing is a dynamic process involving different cell types with distinct roles according to the stages of healing. Fibroblasts and stem cells actively participate in tissue regeneration. A proper stimulation could contribute to enhance wound healing process-es.

The Multifunctionality of Lanthanum-Strontium Cobaltite Nanopowder: High-Pressure Magnetic Studies and Excellent Electrocatalytic Properties for OER.

Simultaneous study of magnetic and electrocatalytic properties of cobaltites under extreme conditions expands the understanding of physical and chemical processes proceeding in them with the possibility of their further practical application. Therefore, LaSrCoO (LSCO) nanopowders were synthesized at different annealing temperatures = 850-900 °C, and their multifunctional properties were studied comprehensively. As increases, the rhombohedral perovskite structure of the LSCO becomes more single-phase, whereas the average particle size and dispersion grow.

Subgroup identification of targeted therapy effects on biomarker for time to event data.

Background: The initiation biomarker-driven trials have revolutionized oncology drug development by challenging the traditional phased approach and introducing basket studies. Notable successes in non-small cell lung cancer (NSCLC) with ALK, ALK/ROS1, and EGFR inhibitors have prompted the need to expand this approach to other cancer sites.

Objectives: This study explores the use of dose response modeling and time-to-event algorithms on the biomarker molecular targeted agent (MTA).

Expansion of the multifunctionality in off-stoichiometric manganites using post-annealing and high pressure: physical and electrochemical studies.

Prospects for the use of manganites in various areas of modern technologies require comprehensive studies of their physical and chemical properties. LaMnO (LMO) ceramics have been synthesized at an annealing temperature of 1150 °C with further post-annealing at 1250, 1350, and 1450 °C. As increases, the structure symmetry changes, and both the crystallite size and chemical defects increase.

Biohybrid Organic Heterostructure Based on Chlorophyll-Bacteriochlorophyll Aggregates for Ecofriendly Hydrogen Production.

Hydrogen energy is an abundant, clean, sustainable and environmentally friendly renewable energy source. Therefore, the production of hydrogen by photocatalytically splitting water on semiconductors has been considered in recent years as a promising and sustainable strategy for converting solar energy into chemical energy to replace conventional energy sources and to solve the growing problem of environmental pollution and the global energy crisis. However, highly efficient solar-driven photocatalytic hydrogen production remains a huge challenge due to the poor visible light response of available photocatalytic materials and the low efficiency of separation and transfer of photogenerated electron-hole pairs.

Role of Nano-miRNAs in Diagnostics and Therapeutics.

MicroRNAs (miRNA) are key regulators of gene expression, controlling different biological processes such as cellular development, differentiation, proliferation, metabolism, and apoptosis. The relationships between miRNA expression and the onset and progression of different diseases, such as tumours, cardiovascular and rheumatic diseases, and neurological disorders, are well known. A nanotechnology-based approach could match miRNA delivery and detection to move beyond the proof-of-concept stage.

Low Concentrated Fractionalized Nanofibers as Suitable Fillers for Optimization of Structural-Functional Parameters of Dead Space Gel Implants after Rectal Extirpation.

Dead space after rectal resection in colorectal surgery is an area with a high risk of complications. In this study, our goal was to develop a novel 3D implant based on composite hydrogels enriched with fractionalized nanofibers. We employed, as a novel approach in abdominal surgery, the application of agarose gels functionalized with fractionalized nanofibers on pieces dozens of microns large with a well-preserved nano-substructure.

Role of miRNA-145, 148, and 185 and Stem Cells in Prostate Cancer.

MicroRNAs (miRNAs) are small non-coding RNA molecules that play a role in cancer linked to the regulation of important cellular processes and pathways involving tumorigenesis, cell proliferation, differentiation, and apoptosis. A lot of human miRNA sequences have been identified which are linked to cancer pathogenesis. MicroRNAs, in prostate cancer (PC), play a relevant role as biomarkers, show a specific profile, and have been used as therapeutic targets.

Smart magnetic nanopowder based on the manganite perovskite for local hyperthermia.

For many medical applications related to diagnosis and treatment of cancer disease, hyperthermia plays an increasingly important role as a local heating method, where precise control of temperature and parameters of the working material is strongly required. Obtaining a smart material with "self-controlled" heating in a desirable temperature range is a relevant task. For this purpose, the nanopowder of manganite perovskite with super-stoichiometric manganese has been synthesized, which consists of soft spherical-like ferromagnetic nanoparticles with an average size of 65 nm and with a narrow temperature range of the magnetic phase transition at 42 °C.

Multifunctionality of lanthanum-strontium manganite nanopowder.

Manganites are multifunctional materials which are widely used in both technology and devices. In this article, new prospects of their use as nanoparticles for various types of applications are demonstrated. For that, the ferromagnetic nanopowder of LaSrMnO has been synthesized by the sol-gel method with a subsequent annealing at 700-900 °C.

Variation of the photoluminescence spectrum of InAs/GaAs heterostructures grown by ion-beam deposition.

This work reports on an experimental investigation of the influence of vertical stacking of quantum dots, the thickness of GaAs potential barriers, and their isovalent doping with bismuth on the photoluminescence properties of InAs/GaAs heterostructures. The experimental samples were grown by ion-beam deposition. We showed that using three vertically stacked layers of InAs quantum dots separated by thin GaAs barrier layers was accompanied by a red-shift of the photoluminescence peak of InAs/GaAs heterostructures.

Obtaining and doping of InAs-QD/GaAs(001) nanostructures by ion beam sputtering.

The features of InAs quantum dots obtained on GaAs(001) single-crystal substrates by ion-beam sputtering were investigated. It has been shown that in the range of ion energies of 150 to 200 eV at a temperature of 500 °C and a beam current of 120 µA InAs quantum dots with average dimensions below 15 nm and a surface density of 10 cm are formed. The technique of controlled doping of InAs/GaAs nanostructures using a SnTe solid-state source was proposed.

[Methods and freezers for obtaining fresh frozen plasma].

Modern methods and apparatuses for freezing polymer containers with plasma are considered. The quality of fresh frozen plasma depends to a considerable extent on the freezer capability to provide high rate of freezing. A criterion curve showing the degree of freezer conformity to standardized documents regulating the requirements to plasma freezers is presented.

[Diagnostic and prognostic validity of high-resolution electrocardiography under the conditions of space flight].

Applicability of high-resolution ECG used in clinics for predicting the probability of life-threatening arrhythmias in cardiovascular patients for the space flight environment was investigated in A 7-d bedrest experiment was to verify HR ECG displayed electrophysiological shifts in myocardial atriums and ventricles. Clearly seen changes in R-amplitude and time course seem to have reflected the volumetric loading and altered sympathetic activity during bed rest QRS-complex had increased the time of low-amplitude signals at the end of the last 40 ms but was short in duration which may point to delayed ventricular depolarization. Prognostically meaningful is exaggerated electrical instability of the myocardium during the standing test on completion of the bedrest period.

[Software for polygraphs used in scientific research].

Polygraphs--devices for simultaneous detection of several physiological parameters--are currently used in medicine in psychology. Special polygraphs are also used in scientific research. The process of data acquisition and processing in such polygraphs is usually computer-controlled.

[Assessment and prediction of health status of the Mars mission crew members].

The scientific concept of health assessment and prediction in a piloted mission to Mars has been built on the principles of pre-nosologic diagnostics, i.e., identification of the norm-pathology borderline states.

[The effect of leukocyte interferon on the kinin system indices of the blood in patients with acute intestinal infections].

The authors studied the efficiency of using rectally interferon in acute intestinal infections, the influence of the agent on the kinin system in these patients. 42 children with bacterial intestinal infections were examined. They were given rectally 1000 IU of interferon.

[Free amino acids and the total middle molecule fraction of the blood serum in patients with continuously progressive paranoid schizophrenia undergoing treatment].

The authors have investigated the levels of free amino acids and of the total fraction of medium molecules in the blood serum of patients with the paranoid form of continuously progressive schizophrenia. It has been demonstrated that these parameters are different in clinically normal individuals versus schizophrenics. The concentrations of free amino acids were the highest in people aged 40 to 50 years (Cys, Ala, Lys, Asp, Thr, Tyr, Try, Val, Leu, Ile) being considerably lower in individuals aged 50 to 60 years (Cys, Ala, Tyr) and over 60 years (Lys, His, Asp, Tyr, Try) which corresponds to the highest activity of the process in patients aged 40 to 50 years and its stabilization in older age.

[Middle molecule fraction in the serum of rats with toxic hepatitis].

An increase in the amount of the middle molecular peptide (MM) fraction in the blood serum of rats with experimental toxic hepatitis and normalization of the MM pool after the administration of the amino acid mixture Alvesin "Novy" are shown. The chromatographic spectra of the MM fraction in normal and experimental animals are compared.

[Thyroid function in persons with hyperplasia of the thyroid gland in the presence of iodine deficiency].

The levels of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (RT3), thyroxine-binding capacity (TBC), a free thyroxine index (FT4I) and thyroid-stimulating hormone (TSH) were studied by a radioimmunoassay in the blood of healthy schoolchildren aged 14 to 17 with stage I-II of thyroid hyperplasia residing in a mountain region of the Transcarpathian area, the Ukrainian SSR, with noticeable environmental iodine deficiency. Similar studies were conducted in a lowland region with a sufficient iodine level. A decrease in the concentration of T4, T3, RT3 and FT4I and higher TBC and TSH values were established in the healthy schoolchildren from the mountain region as compared to corresponding values in the schoolchildren from the lowland region indicating a lower level of homeostasis of thyroid hormones in the mountain region.