Feasibility and Reaction Thresholds of Double-Blind, Placebo-Controlled Peanut and Nut Food Challenges Using Gingerbread Matrix.

Introduction: Double-blind, placebo-controlled food challenges are an important tool in diagnosing food allergies. PRACTALL recommends a dose-escalation schedule of 3-3,000 mg of food protein and a top dose of at least 2,000 mg to avoid false-negative results. This retrospective observational study tests the thresholds and feasibility using a previously published gingerbread matrix.