The business case for a healthy office; a holistic overview of relations between office workspace design and mental health.

The role of the physical workspace in employee mental health is often overlooked. As a (mentally) healthy workforce is vital for an organisation's success, it is important to optimise office workspace conditions. Previous studies on the effects of the physical workspace on mental health tended to focus on the effects of a specific element of the physical workspace on one or only a few mental health indicators.

Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory.

It is well established that Zif268/Egr1, a member of the Egr family of transcription factors, is critical for the consolidation of several forms of memory; however, it is as yet uncertain whether increasing expression of Zif268 in neurons can facilitate memory formation. Here, we used an inducible transgenic mouse model to specifically induce Zif268 overexpression in forebrain neurons and examined the effect on recognition memory and hippocampal synaptic transmission and plasticity. We found that Zif268 overexpression during the establishment of memory for objects did not change the ability to form a long-term memory of objects, but enhanced the capacity to form a long-term memory of the spatial location of objects.