Publications by authors named "Pascal Schweizer"
DPPG-Based Thermosensitive Liposomes with Encapsulated Doxorubicin Combined with Hyperthermia Lead to Higher Doxorubicin Concentrations in the Bladder Compared to Conventional Application in Pigs: A Rationale for the Treatment of Muscle-Invasive Bladder Cancer.
F Johannes P van Valenberg Iris S G Brummelhuis Lars H Lindner Felix Kuhnle Barbara Wedmann Pascal Schweizer
Int J Nanomedicine
January 2021
Purpose: Current treatment options for muscle-invasive bladder cancer (MIBC) are associated with substantial morbidity. Local release of doxorubicin (DOX) from phosphatidyldiglycerol-based thermosensitive liposomes (DPPG-TSL-DOX) potentiated by hyperthermia (HT) in the bladder wall may result in bladder sparing without toxicity of systemic chemotherapy. We investigated whether this approach, compared to conventional DOX application, increases DOX concentrations in the bladder wall while limiting DOX in essential organs.
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- The study investigates why hereditary nonpolyposis colon cancer (HNPCC) primarily affects the colorectum and uterine endometrium, focusing on the role of deficient DNA mismatch repair (MMR).
- It analyzes microsatellite instability patterns in colorectal and endometrial cancers from patients with the same MMR gene mutations (MLH1 or MSH2) and finds significant differences in instability profiles between the two cancer types.
- Colorectal cancers show a clear instability pattern, while endometrial cancers display more variability and a lower average number of unstable markers, suggesting organ-specific factors influence cancer development in HNPCC.