Gaussian processes modeling for the prediction of polymeric nanoparticle formulation design to enhance encapsulation efficiency and therapeutic efficacy.

Conventional drugs have been facing various drug delivery obstacles, including first-pass metabolism for oral medications, drug degradation by cellular enzymes, off-target effects, and cytotoxicity of healthy cells. Nanoparticles (NP) application in drug delivery can compensate for these drawbacks to a great extent. NPs can be fabricated using different materials and structures to achieve desired therapeutic effects.

Energy Efficient Execution of POMDP Policies.

Recent advances in planning techniques for partially observable Markov decision processes (POMDPs) have focused on online search techniques and offline point-based value iteration. While these techniques allow practitioners to obtain policies for fairly large problems, they assume that a nonnegligible amount of computation can be done between each decision point. In contrast, the recent proliferation of mobile and embedded devices has lead to a surge of applications that could benefit from state-of-the-art planning techniques if they can operate under severe constraints on computational resources.

Upper limb contributions to frontal plane balance control in rollator-assisted walking.

While assisting with balance is a primary reason for rollator use, few studies have examined how the upper limbs are used for balance. This study examines upper limb contributions to balance control during rollator-assisted walking. We hypothesized that there would be an increased upper limb contribution, measured by mean vertical loading (Fz) and variation in frontal plane center-of-pressure (COPhigh), when walking balance is challenged/impaired.

Transparent muscle characterization using quantitative electromyography: different binarization mappings.

Evaluation of patients with suspected neuromuscular disorders is typically based on qualitative visual and auditory assessment of needle detected eletromyographic (EMG) signals; the resulting muscle characterization is subjective and highly dependent on the skill and experience of the examiner. Quantitative electromyography (QEMG) techniques were developed to extract motor unit potential trains (MUPTs) from needle detected EMG signals, and estimate features capturing motor unit potential (MUP) morphology and quantifying morphological consistency across MUPs belonging to the same MUPT. The aim of this study is to improve available methods for obtaining transparent muscle characterizations from features obtained using QEMG techniques.

Measuring life space in older adults with mild-to-moderate Alzheimer's disease using mobile phone GPS.

Background: As an indicator of physical and cognitive functioning in community-dwelling older adults, there is increasing interest in measuring life space, defined as the geographical area a person covers in daily life. Typically measured through questionnaires, life space can be challenging to assess in amnestic dementia associated with Alzheimer's disease (AD). While global positioning system (GPS) technology has been suggested as a potential solution, there remains a lack of data validating GPS-based methods to measure life space in cognitively impaired populations.

Towards a mobility diagnostic tool: tracking rollator users' leg pose with a monocular vision system.

Cognitive assistance of a rollator (wheeled walker) user tends to reduce the attentional capacity of the user and may impact her stability. Hence, it is important to understand and track the pose of rollator users before augmenting a rollator with some form of cognitive assistance. While the majority of current markerless vision systems focus on estimating 2D and 3D walking motion in the sagittal plane, we wish to estimate the 3D pose of rollator users' lower limbs from observing image sequences in the coronal (frontal) plane.

A planning system based on Markov decision processes to guide people with dementia through activities of daily living.

Older adults with dementia often cannot remember how to complete activities of daily living and require a caregiver to aid them through the steps involved. The use of a computerized guidance system could potentially reduce the reliance on a caregiver. This paper examines the design and preliminary evaluation of a planning system that uses Markov decision processes (MDPs) to determine when and how to provide prompts to a user with dementia for guidance through the activity of handwashing.