Publications by authors named "Pascal Le Prince"
Article Synopsis
- Coronary artery disease often coexists with aortic stenosis, and transcatheter aortic valve implantation (TAVI) has been recognized as a therapeutic option for younger, lower-risk patients who may need future coronary interventions.
- In a study analyzing 1,936 TAVI patients, only 3.5% required coronary access (CA) within 3 years post-TAVI, with successful CA achieved in all cases and a high clinical success rate (97.9%) for percutaneous coronary interventions.
- The findings indicated that the CA group had higher rates of coronary artery disease and related conditions; however, cardiovascular mortality was notably higher in the CA group compared to those without CA.
Rationale: Fibro-fatty infiltration of subepicardial layers of the atrial wall has been shown to contribute to the substrate of atrial fibrillation.
Objective: Here, we examined if the epicardium that contains multipotent cells is involved in this remodeling process.
Methods And Results: One hundred nine human surgical right atrial specimens were evaluated.
The abundance of epicardial adipose tissue (EAT) is associated with atrial fibrillation (AF), the most frequent cardiac arrhythmia. However, both the origin and the factors involved in EAT expansion are unknown. Here, we found that adult human atrial epicardial cells were highly adipogenic through an epithelial-mesenchymal transition both in vitro and in vivo.
View Article and Find Full Text PDFAims: Accumulation of atrial adipose tissue is associated with atrial fibrillation (AF). However, the underlying mechanisms remain poorly understood. We examined the relationship between the characteristics of fatty infiltrates of the atrial myocardium and the history of AF.
View Article and Find Full Text PDFAim: Transcatheter aortic valve implantation has become an alternative to surgery in higher risk patients with symptomatic aortic stenosis. The aim of the ADVANCE study was to evaluate outcomes following implantation of a self-expanding transcatheter aortic valve system in a fully monitored, multi-centre 'real-world' patient population in highly experienced centres.
Methods And Results: Patients with severe aortic stenosis at a higher surgical risk in whom implantation of the CoreValve System was decided by the Heart Team were included.
Background: The incidence of mediastinitis after heart transplantation has been reported to be between 2.5% and 7.5%.
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