Publications by authors named "Pascal K Harimech"

We demonstrate a new method to reversibly cross-link DNA-nanoparticle dimers, trimers, and tetramers using light as an external stimulus. A DNA interstrand photo-cross-linking reaction is possible via ligation of a cyano-vinyl carbazole nucleoside with an opposite thymine when irradiated at 365 nm. This reaction results in nanoparticle assemblies that are not susceptible to DNA dehybridization conditions.

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A fluorescence-based particle sensor for oxaloacetic acid is presented. In the presence of nicotinamide adenine dinucleotide as a cofactor, oxaloacetic acid is converted by malate dehydrogenase into l-malic acid. The progress of the reaction is monitored by sensing of proton consumption with an integrated pH sensor.

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In the past decade gold nanoparticle-nucleic acid conjugates became progressively important for biomedical applications. Fluorophores attached to nucleic acid-gold nanoparticle conjugates have opened up a new era of biological sensing. The most promising advancement in this field was the invention of the so-called 'nano-flare' systems.

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