Publications by authors named "Pascal Antoine"

Objectives: BRCA1/2 pathogenic variants have been associated with an increased risk for breast, ovarian, pancreatic, prostate cancer as well as melanoma. The present research uses the Leventhal's common-sense model of self-regulation (CSM), a theoretical framework highlighting the role of mental representations on responses to a health-threat. We aim at understanding the personal meaning and representation of living with an hereditary breast and ovarian cancer predisposition.

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Background: Alzheimer's disease (AD) is characterized by severe memory alterations, affecting especially memories of personal past events. Until now, autobiographical memory impairments have been characterized using formal memory assessments, requiring patients to strategically and deliberately recall past events. However, contrary to this highly cognitively demanding mode of memory recall, autobiographical memories frequently come to mind unexpectedly based on automatic associative processes.

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Purpose: The onset of paediatric cancer leads to changes in the functioning of the parental couple. The interactions and interdependence between partners affect their individual and dyadic adjustments. Hope can enable parents to cope with difficulties and alleviate their distress.

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The main objective of this study was to identify the facilitators of and barriers to the transition from pediatric to adult care for adolescents and young adults (AYAs) with cancer according to physicians and nurses working in oncology. The secondary objectives were (1) to explore the viewpoints of health care professionals (HCPs) on this transition and (2) to discover HCP's needs and the needs they perceive among AYAs and their parents. Semistructured interviews were conducted with 19 HCPs to discover their experiences with pediatric to adult care transitions.

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Objectives: We assessed whether individuals with mild Alzheimer's disease (AD), despite some deficits in autobiographical memory, could effectively convey their personal experiences through storytelling.

Methods: We invited 37 individuals with mild AD and 37 control participants to share their personal experiences. We rated these narratives based on five characteristics of storytelling: focus, reflection, entertainment, structure, and specificity.

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Background: The potential of ChatGPT in medical diagnosis has been explored in various medical conditions.

Objective: We assessed whether ChatGPT can contribute to the diagnosis of Alzheimer's disease (AD).

Methods: We provided ChatGPT with four generated cases (mild, moderate, or advanced stage AD dementia, or mild cognitive impairment), including descriptions of their complaints, physical examinations, as well as biomarker, neuroimaging, and neuropsychological data.

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Background: For couples facing Parkinson's disease, marital relationships are significantly impacted, even at the early stages of the disease. However, very few studies have explicitly explored the functioning of the couple and how both partners deal with Parkinson's disease. The aim of this study was to explore the experiences and strategies of couples facing Parkinson's disease in the early stage using dyadic interpretative phenomenological analysis.

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Neurodegenerative diseases (NDDs) pose significant challenges to couple relationships. Existing research has predominantly focused on the impact of Alzheimer's disease (AD) on various types of dyads, resulting in significant advances in the field. However, despite a keen interest in transdiagnostic approaches , a comprehensive review addressing dyadic processes underlying the functioning of couple relationships across different NDDs is lacking.

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Article Synopsis
  • The study investigates the relationship between future thinking and prospective memory in individuals with Alzheimer's disease (AD).
  • Participants engaged in tasks measuring both event-based and time-based prospective memory as well as a future thinking exercise involving imagining upcoming events.
  • Results showed that AD participants performed worse than control participants in both memory tasks and future thinking, highlighting the interconnected decline in these cognitive processes for those with AD.
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Background: Digital health technologies have expanded tremendously in the last two decades, creating an emerging research and clinical field. They are regarded as cost-effective, and their use in healthcare is prioritized by many countries. However, the constant evolution of these technologies has led to an abundance of related literature.

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Impaired awareness increases dependency of patients suffering from Alzheimer's Disease (AD) and caregivers' burden but remains insufficiently evaluated in clinical practice. The numerous conceptualisations of this symptomatology (anosognosia, denial, insight…) have only a slight impact on the three main assessment methodologies which are: the patient-caregiver discrepancy; the clinician rating of patients' awareness of illness; and the prediction of performance discrepancy methods. Nevertheless, most of evaluating tools are not validated yet, in particular regarding the clinician rating, leading to contrasted results.

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Imagery work is a useful therapeutic tool in the treatment of depression. It is central in different therapeutic approaches, such as cognitive behavioral therapy and compassion-focused therapy. The clinical case of Cynthia is presented.

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Introduction: The public health issue of the Parkinson's disease (PD) has led to a great deal of research that has highlighted the individual challenges faced by the person with the Parkinson's disease (PwPD) and the caregiving spouse. Few studies, however, have sought to understand the functioning of couples facing PD, by differentiating each stage, each of which has its own issues. In particular, the "honeymoon period", characterized by a symptomatic respite allowed by the effectiveness of treatments for motor symptoms, has been poorly documented, especially at the dyadic level.

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: Theoretical models in informal dementia care have been developed to understand how risk and protective factors interact to cause caregiver's distress. The development of psychological network analysis provides a rich complement to our current models, as explores how different variables (or nodes) are associated using graph theories. : The present study explored the use of network analysis using data from 125 informal caregivers of their partner with dementia (PwD).

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Background: The objective of this study was twofold. We assessed whether individuals with Alzheimer's disease (AD) demonstrate higher empathy toward people with the same disorder. We also assessed whether empathy may enhance the recognition of these peoples' faces.

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Article Synopsis
  • A study examined how individuals with Alzheimer's disease (AD) envision their future selves compared to healthy individuals by asking them to create "I-will-be" statements.
  • Results showed that AD patients produced fewer statements overall, indicating a weakened ability to form future self-concepts.
  • The analysis revealed AD patients focused more on self-cessation (ideas about death) and had significantly fewer statements related to their physical, social, and psychological selves compared to healthy controls.
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Background: Diagnosis of Alzheimer disease (AD) can cause substantial psychological distress in patients. We thus assessed how patients with AD remember the announcement of diagnosis.

Methods: We recruited 47 participants with mild AD (26 women; M age=68.

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Previous studies have reported the major role of apathy in awareness assessment among Alzheimer's patients using the patient-caregiver discrepancy method, whatever the awareness dimension assessed. Using the Apathy Evaluation Scales among other awareness scales, we report that apathy is the sole awareness dimension distinguishing healthy controls (25), mild (57) and moderate-to-moderately-severe (11) Alzheimer's patients. A linear regression showed that the Mini-Mental State Examination score used as a risk factor for non-awareness was the only factor associated with awareness of apathy and was the best predictor.

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Article Synopsis
  • - The study investigates how Parkinson's disease (PD) affects the dynamics of couples' relationships, focusing specifically on experiences during the advanced stage of the disease.
  • - Through interviews with 15 patients and their partners, three main themes emerged: emotional distancing due to intimacy, the critical role of the assisting partner's support, and the shared emotional regulation in facing an uncertain future.
  • - The findings highlight the need for psychological support to help couples communicate their feelings and needs as they navigate the challenges posed by Parkinson's disease.
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To understand awareness and fluctuations of awareness in Alzheimer's disease (AD), it is fruitful to consider the objects of awareness, e.g., cognitive functioning or recognition of the disease, as well as the mechanisms and modes of expression underlying awareness.

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Background And Aims: Autobiographical memory serves to recall past personal experiences and share them with others, promoting social bonding and communication. In this study, we investigated whether encouraging patients with Alzheimer's disease (AD) to share autobiographical memories during formal neuropsychological testing may boost the patient-clinician relationship, and more specifically, the neuropsychologist's level of sympathy as perceived by patients.

Methods: We invited patients with mild AD to perform neuropsychological testing in two conditions.

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Article Synopsis
  • A study examined whether Alzheimer's Disease patients perform differently on neuropsychological tests when their spouses are present versus when they are alone.
  • The results indicated no significant differences in cognitive abilities, memory, inhibition, or depression levels based on the presence of spouses, but patients had better verbal fluency when tested alone.
  • Clinicians can test patients with or without spouses for most assessments, but for verbal fluency, it's recommended to test patients alone or consider the spouse's presence when interpreting results.
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Objective: This study assessed the ability of patients with Alzheimer's Disease (AD) to produce "when, where, and who" information during future thinking.

Methods: AD patients and control participants were invited to imagine future scenarios. Future thinking was analyzed with respect to the number of "when, where, and who" details.

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Background: The increased tasks and responsibilities involved in supporting a parent with dementia (PWD) can induce distress in adult-child caregivers. Previous studies have shown that distress can be influenced by PWD and caregiver determinants, but few studies have considered the associations between these variables.

Objective: This study tested a complex model of adult-child caregiver distress in which PWD and caregiver determinants and their associations are considered.

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Most research has mainly focused on the decline of the subjective experience in Alzheimer's disease (AD). However, few attempts have been made to evaluate whether subjective experience may be maintained in AD. In this narrative review, we attempt to provide a positive view, according to which patients with AD can enjoy, to some extent, subjective experience during memory retrieval.

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