Determination of the Handedness of Urea Inclusion Compounds.

Invited for the cover of this issue is the group of Bo Wang at Biogen. The image depicts the sectored chiral domains of urea inclusion compounds. Read the full text of the article at 10.

Determination of the Handedness of Urea Inclusion Compounds.

Since the discovery of urea inclusion compounds (UICs) in 1940, the handedness of this chiral helical system has not been established experimentally. Here three UIC systems containing only light atoms were studied. The optical rotations were first measured, and the absolute structures of the enantiomorphic domains of three UICs were determined by single crystal X-ray diffraction (SCXRD).