Correlation between cardiac enzyme elevation and the duration of cardiopulmonary resuscitation.

Cardiovascular disease is the leading cause of death in the United States. Acute myocardial infarction (MI) is defined as necrosis of myocardial cells. Several studies have shown that cardiac markers are elevated after successful cardiopulmonary resuscitation (CPR) due to physical as well as electrical trauma.

Prevalence of hypertension in Lithuanian mariners.

Several international studies from Spain, the Netherlands, Poland, Croatia, and Finland indicate contradicting findings regarding cardiovascular dysfunction among seamen, deep sea fishermen, and harbor workers. The purpose of the present survey was to evaluate the prevalence of hypertension in a selected group of Lithuanian seamen. The survey was conducted during a one year period and involved sailors from commercial, passenger, and fishing boats.

Cardiac rate normalization in chronic atrial fibrillation: comparison of long-term efficacy of treatment with amiodarone versus AV node ablation and permanent His-bundle pacing.

Chronic atrial fibrillation (AF) is a common arrhythmia with significant morbidity and mortality. AF has been the subject of considerable attention and intensive clinical research in recent years. Current opinion on the management of AF favors the restoration and maintenance of normal ventricular rhythm.

Reactive oxygen species increased focal adhesion kinase production in pulmonary microvascular endothelial cells.

Focal adhesion kinase (FAK) is a 125 kDa protein tyrosine kinase (PTK) associated with focal adhesion in many cells, which plays a major role in the integrity of cytoskeletal structure. Reactive oxygen species produced during ischemia and reperfusion injury has been found to be an important mediator of signal transduction process. We found that low dose H2O2 induced increased FAK production in pulmonary microvascular endothelial cells, which could be blocked by cycloheximide (CHX), a protein synthesis inhibitor.

Inhibition of human CD24 binding to platelet-bound P-selectin by monoclonal antibody.

P-selectin, an adhesive molecule present on the surface of activated platelets, participates in the interactions between platelets and a variety of cells, including cancer cells. Such interaction is an important step toward the establishment of thriving secondary tumors during blood-borne metastasis. CD24, one of the mucin-type ligands of P-selectin, is expressed in various adenocarcinomas and may mediate the interaction between platelets and cancer cells.