Publications by authors named "Parya Alizadeh Khosroshahi"
MicroRNA dysregulation in glutamate and dopamine pathways of schizophrenia: From molecular pathways to diagnostic and therapeutic approaches.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Schizophrenia is a complex psychiatric disorder, and genetic and environmental factors have been implicated in its development. Dysregulated glutamatergic and dopaminergic transmission pathways are involved in schizophrenia development. Besides genetic mutations, epigenetic dysregulation has a considerable role in dysregulating molecular pathways involved in schizophrenia.
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- MicroRNAs (miRNAs) play a key role in brain development and dysregulation can lead to psychiatric disorders like schizophrenia; the miR-29 family is particularly implicated in brain maturation.
- This study analyzed serum samples from 42 schizophrenia patients and 40 healthy controls, revealing that miR-29a levels were significantly lower in patients, especially in certain types of schizophrenia.
- miR-29a showed potential as a diagnostic biomarker, with 80% specificity and 71.43% sensitivity, indicating its relevance in understanding and diagnosing schizophrenia.