Publications by authors named "Parviz Mehraein"
Article Synopsis
- The study aimed to analyze the histopathological changes in patients with CADASIL, focusing on enucleated eyes.
- Four eyes from two patients were examined post-autopsy using various microscopy techniques, revealing significant vascular changes.
- The results indicated a distinct pattern of blood vessel involvement, highlighting pronounced loss of vascular smooth muscle cells in certain areas, which supports previous findings about the effects of CADASIL on brain tissue.
Background: Tenascin-C (TN-C), a large extracellular matrix (ECM) glycoprotein with a molecular weight of 180-250 kilodaltons, is present in several normal adult tissues. TN-C is up-regulated during embryogenesis, in wound healing, and in tumor tissues. Glioblastoma multiforme (GBM) is the most frequent and malignant astrocytic tumor comprised of poorly differentiated, neoplastic astrocytes.
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