Publications by authors named "Parveez A Abdul-Azees"
Article Synopsis
- There is a pressing need for effective treatments for denture stomatitis (DS) among denture wearers, and this study explores the use of nanohydroxyapatite (nanoHAP) nanoparticles to combat biofilm formation by Candida albicans on denture bases made of PMMA.
- The research involved creating shared conditions for testing where PMMA disks were treated with either an antibacterial denture cleanser, a nanoHAP mouthwash, or distilled water, and biofilm growth was analyzed through various microscopy techniques.
- Results indicated that nanoHAP mouthwash significantly inhibited biofilm formation and reduced biofilm biomass and thickness compared to other treatments, suggesting its potential effectiveness in preventing DS in clinical settings.
Article Synopsis
- This study analyzed how effective Isomalt-containing toothpaste is in preventing dental caries compared to traditional fluoride toothpaste.
- Human dental enamel slabs were tested under different conditions, using various toothpaste formulations over a week-long period with plaque exposure.
- Results showed that toothpaste with 10% Isomalt, fluoride, and CPC was significantly more effective at reducing demineralization and caries development than toothpaste containing only fluoride.
Objectives: The effectiveness of an Isomalt-containing mouthrinse to prevent caries development was investigated.
Methods: Human enamel blocks were randomly assigned to five groups (n = 30/group): De-ionized distilled water (DDW), and mouthrinse containing either (IFC) 1% Isomalt, 225 ppm fluoride, and 0.05% cetylpyridinium chloride (CPC), (IF) 1% Isomalt and 225ppm fluoride, (FC) 225 ppm fluoride and 0.
Article Synopsis
- Oral health is really important for older people, but we don't understand it well because studying it with animal models is tricky.
- This study looked at marmosets (a type of small monkey) to understand how oral health changes as they age, comparing young, middle-aged, and older groups.
- The results showed that older marmosets had more tooth problems and certain bacteria in their mouths, suggesting that studying these monkeys can help us learn about the effects of aging on human oral health.
Purpose: Denture Stomatitis, a chronic mucosal inflammation associated with Candida albicans, is common among denture wearers. Several health conditions have been linked to chronic Candida infections. The complex, multifactorial nature of denture stomatitis requires the continuous pursuit of effective long-term solutions.
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- The study aimed to examine how radiofrequency (RF) energy from a power toothbrush affects the structure and bacteria in dental plaque, which can lead to better dental hygiene practices.
- Using ToothWave, researchers treated dental plaque samples with RF energy over different time intervals and compared the results to control samples that didn’t receive RF treatment.
- Results showed that RF significantly reduced viable bacteria in plaque and altered its structure, indicating that RF energy can disrupt plaque effectively, especially when combined with toothpaste.
This study validated a microbial caries model (artificial mouth) for dental caries development to determine the optimal time to create early caries suitable for evaluation of the efficacy of caries therapeutic agents. In all, 40 human enamel blocks were placed in an artificial mouth at 37 °C and 5% CO and were exposed to brain heart infusion broth inoculated with in continuous circulation (0.3 mL/min).
View Article and Find Full Text PDFBackground: Current treatments for salivary gland (SG) hypofunction are palliative and do not address the underlying cause or progression of the disease. SG-derived stem cells have the potential to treat SG hypofunction, but their isolation is challenging, especially when the tissue has been damaged by disease or irradiation for head and neck cancer. In the current study, we test the hypothesis that multipotent bone marrow-derived mesenchymal stem cells (BM-MSCs) in a rat model are capable of trans-differentiating to the SG epithelial cell lineage when induced by a native SG-specific extracellular matrix (SG-ECM) and thus may be a viable substitute for repairing damaged SGs.
View Article and Find Full Text PDFPurpose: To determine the efficacy of an oral spray and oral rinses to inhibit oral cariogenic dual species biofilm formation on hydroxyapatite (HA) discs.
Methods: The Streptococcus mutans (NCTC 10449, ATCC), Lactobacilli casei (NCIB 8820, ATCC) dual species biofilm formation and inhibition on HA disc was tested using five antimicrobial products, i.e.
Objectives: The aim of this randomized, double-blind, two-arm crossover in situ study was to investigate whether nano-hydroxyapatite (nanoHAP) dental lotion (Apagard Deep Care) applied immediately after tooth-brushing with nanoHAP toothpaste (Apagard M-plus) enhances the remineralization promotion and the demineralization inhibition efficacies of nanoHAP toothpastes.
Methods: 64 sound enamel blocks and 64 blocks bearing artificially-produced initial caries were produced from human permanent molar teeth. During each treatment period, lasting 14 days per arm, two blocks, one sound and one lesion-bearing, were exposed to either 5% nanoHAP-containing or placebo dental lotion after tooth-brushing with 5% nanoHAP toothpaste, via an intra-oral appliance worn by 30 adults in each of the study groups.
Statement Of Problem: Denture stomatitis is a chronic inflammatory condition caused by the formation of Candida albicans biofilm on denture bases. It is associated with aggravating intraoral pain, itching, and burning sensations. It can also potentiate cardiovascular diseases and aspiration pneumonia.
View Article and Find Full Text PDFNonalcoholic fatty liver disease (NAFLD) is a spectrum of disorders ranging from hepatic steatosis [excessive accumulation of triglycerides (TG)] to nonalcoholic steatohepatitis, which can progress to cirrhosis and hepatocellular carcinoma. The molecular pathogenesis of steatosis and progression to more severe NAFLD remains unclear. Obesity and aging, two principal risk factors for NAFLD, are associated with a hyperadrenergic state.
View Article and Find Full Text PDFFrom acid corroded iron plates five different types of actinobacteria were isolated. Among the five, JMCACA3 strain was selected for the present study. In ISP media, JMCACA3 strain showed well-developed aerial and substrate mycelia were observed.
View Article and Find Full Text PDFObjective: The present in vitro study investigated if simulated daily use of hydroxyapatite-based gel (15% HAP) remineralizes early caries lesions as effective as weekly use of high fluoride (12,500 ppm) concentration gel, comparing them with artificial saliva alone.
Materials And Methods: Three tooth blocks were produced from each of 20 bovine teeth. Caries-like lesion was created on each block by 4-day demineralization in acidified gel.
Objective: This in situ study compared the effectiveness of two toothpastes containing hydroxyapatite or 500 ppm fluoride in promoting remineralization and inhibiting caries development.
Materials And Methods: Two enamel blocks (human primary teeth), one sound and one with artificially-produced caries lesion, were exposed to toothpaste containing either 10% hydroxyapatite or 500 ppm F (amine fluoride) via intra-oral appliance worn by 30 adults in two-arm double blind randomized crossover study lasting 14 days per arm (ClinicalTrials.gov: NCT03681340).
Aim: Oral malodor is a common condition caused by some Gram-negative oral bacteria, among which are the 3 red complex bacteria (RCB). The present study investigated the effectiveness of the Ultrasound Tongue Scraper (UTS) to disrupt the structural morphology of the bacteria and their biofilm.
Methods: While developing over 72 hours, multispecies biofilms of RCB (Porphromonas gingivalis, Tryponema denticola, Tannerella forsythia) were treated every 24 hours with 1.