Publications by authors named "Parveen S Akhtar"
Aim: Spermidine/spermine N-acetyltransferase (SSAT-1) regulates cell growth, proliferation and death. Amantadine is converted by SSAT-1 to acetylamantadine (AA). In our earlier studies, although SSAT-1 was activated in patients with cancer, a number of ostensibly healthy adult volunteers had higher than expected AA concentration.
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- Lung cancer is the leading cause of cancer-related deaths globally, making early diagnosis essential for improving treatment outcomes.
- The study investigates the use of metabolomics, specifically focusing on the SSAT-1/polyamine pathway, to differentiate between lung cancer patients and healthy individuals using plasma samples.
- A panel of 14 metabolites was identified, achieving a high accuracy rate (0.97 AUC), suggesting it could serve as a specific diagnostic tool and aid in monitoring treatment responses for lung cancer.
Aim: Spermidine/spermine N-acetyltransferase (SSAT-1) plays a critical role in cell growth, proliferation and death, and is known to be activated in human cancer cells. Amantadine, a US FDA-approved antiviral drug, is a substrate for SSAT-1 and can be used to indirectly measure SSAT-1 activity because of its conversion to acetylamantadine (AA). This study was undertaken to further validate SSAT-1 activity in breast and lung cancer patients.
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