Publications by authors named "Parul Vadgama"
Effectiveness and Safety of Varying Doses of Linezolid With Bedaquiline and Pretomanid in Treatment of Drug-Resistant Pulmonary Tuberculosis: Open-Label, Randomized Clinical Trial.
Chandrasekaran Padmapriyadarsini Vikas S Oswal Chetankumar D Jain Muthu Vijayalakshmi Mariappan Neeta Singla Parul Vadgama
Clin Infect Dis
December 2024
Article Synopsis
- The study examined the effectiveness and safety of reducing linezolid doses in a treatment regimen for adults with pre-extensively drug-resistant or treatment-intolerant multidrug-resistant tuberculosis.
- Patients were enrolled in a clinical trial where they were randomly assigned to three different dosing regimens of linezolid, alongside bedaquiline and pretomanid, for a total duration of 26 weeks.
- Results showed that the reduced dose of linezolid (300 mg/day) maintained similar cure rates as the standard dose (600 mg/day) while leading to fewer reported cases of peripheral neuropathy, suggesting a safer approach for treating this condition.
Background: In a close knit congregation such as prison, Tuberculosis (TB) and HIV can be major health problems. However, their prevalence in Indian prisons is under reported. This study aimed at adopting a camp based, active case finding approach to identify cases of TB, HIV and at risk prisoners in a central prison of South Gujarat.
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