Discovery and pharmacological evaluation of indole derivatives as potent and selective RORγt inverse agonist for multiple autoimmune conditions.

Targeting nuclear receptor RORγ is recognized to be beneficial in multiple autoimmune disorders. We disclosed new indole analogues as potent RORγ inverse agonists. RO-2 as one of the potent and orally bioavailable compounds was evaluated in various models of autoimmune disorder.

Determination of sex from an autopsy sample of adult hyoid bones.

Determination of sex is the first and crucial step in the process of identifying human remains in forensic casework. Sex determination from skeletal remains is well studied and an extensively documented subject. The hyoid bone, however, has drawn less attention in studies of this nature.

Forensic diagnosis and classification of snakebite (neurotoxic and haemotoxic) from renal changes at autopsy: morphological and histological determinants using a semi-quantitative method.

Mortality due to poisonous snakebite is an emerging public health concern. Of late, snakebite has drawn global attention. Snakebite is a well-known cause of renal pathology especially in the haemotoxic group.

Morphometric features and sexual dimorphism of adult hyoid bone: a population specific study with forensic implications.

Hyoid is a U-shaped bone present in the ventral aspect of neck at the level of fourth cervical vertebra. Morphological variants of hyoid are well documented. The present study was designed to identify these morphological features and examine the sexual dimorphism of adult hyoid bone in Indian Bengali population.

Predictors of hyoid fracture in hanging: Discriminant function analysis of morphometric variables.

Hyoid is a U-shaped bone present in the ventral aspect of neck at the level of fourth cervical vertebra. It is a small bone placed between the root of tongue and the thyroid cartilage. Fracture of hyoid has great significance and importance in forensic pathology.

Intraoperative hydrostatic reduction of intussusception.

Aims: To find out an easier way of reduction of intussusception during open surgery to avoid unnecessary bowel injury.

Materials And Methods: Under general anesthesia, before laparotomy, warm normal saline was infused into the rectum with a Foley catheter and an intravenous drip set maintaining the level of the bottle at 80 cm above the operating table. After opening the abdomen, pressure was applied on the colon filled with normal saline distal to the intussusceptum.