Publications by authors named "Partha P Medhi"

Article Synopsis
  • The study aimed to evaluate treatment outcomes and patterns of failure in non-metastatic nasopharyngeal carcinoma (NPC) patients who received radiation therapy with or without chemotherapy at a cancer center in northeast India between February 2018 and February 2022.
  • Researchers analyzed the treatment results of 99 patients, focusing on survival rates and the influence of tumor and nodal volumes on prognosis, using statistical methods like the Cox proportional hazards model and ROC analysis.
  • Key findings revealed that 35.4% of patients experienced recurrence, with significant associations between tumor volume and survival outcomes; specifically, both primary tumor and nodal volumes were identified as important independent prognostic indicators for overall and progression-free survival.
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Head and neck oncology represents a complex and challenging field, encompassing the diagnosis, treatment and management of various malignancies affecting the intricate anatomical structures of the head and neck region. With advancements in artificial intelligence (AI), chatbot applications have emerged as a promising tool to revolutionize the field of Head and Neck oncology. ChatGPT is a cutting-edge language model developed by OpenAI that can help the oncologist in the clinic in scheduling appointments, establishing a clinical diagnosis, making a treatment plan and follow-up.

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Head and neck cancer incidence is relatively higher in north-eastern states than in other parts of India. Intensity-modulated radiotherapy (IMRT) was first introduced in our institute in 2012 to cater the entire north-east. This study attempts to assess the treatment outcomes and prognostic factors of head and neck cancer patients who had been treated with definitive radiotherapy in our institute from 2012 to 2016 using IMRT.

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Purpose: High-grade gliomas are highly fatal disease with poor prognosis despite multimodality management. Inflammatory biomarkers are widely used for prognostication in various solid malignancies to stratify high risk patients. The current research was conducted to investigate whether any change in neutrophil-lymphocyte ratio (NLR) during adjuvant chemoradiotherapy has any prognostic significance in high-grade glioma patients.

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Article Synopsis
  • High-grade gliomas (HGG) are aggressive brain tumors that lead to significant cognitive decline in patients receiving treatment despite advanced care methods.
  • A study involving 53 patients revealed that 56.6% experienced cognitive impairment following treatment, with specific tumor types and treatment factors correlated to this decline.
  • The findings suggest that neurocognitive decline in HGG is influenced by a combination of tumor characteristics, patient factors, and treatment effects, highlighting its multifactorial nature.
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The aim is to retrospectively evaluate the clinical outcomes and prognostic factors in patients of locally advanced nasopharyngeal cancer (NPC) treated with intensity-modulated radiotherapy (IMRT). The northeastern states report relatively more NPC cases in comparison to other states of India. This study is an attempt to assess the treatment outcomes and prognostic factors of locally advanced NPC who had been treated with definitive radiotherapy with or without chemotherapy in our institute from 2012 to 2016 using IMRT.

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Head and neck cancer (HNC) patients undergoing curative radiotherapy (RT) are at risk of malnutrition due to disease process as well as effects of therapy. Identifying the nutritional status of these patients at the earliest, helps to introduce adequate and timely interventions that can improve compliance and outcomes of treatment. Various tools for nutritional assessment in cancer patients have been proposed.

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Background: Almost all the patients receiving curative radiotherapy for head and neck cancer develop radiation dermatitis, which many a times leads to treatment interruption and reduce patient compliance. In this study, we evaluated the effect of potent topical steroid (Betamethasone Valerate 0.1%) cream on acute radiation dermatitis in head and neck cancer patients receiving curative radiotherapy.

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Aim: The aim is to retrospectively evaluate the clinical outcomes and treatment related toxicities in patients of synchronous esophageal and head & neck cancer when treated with definitive radiotherapy with or without concurrent chemotherapy.

Background: Patients of esophageal cancer with a synchronous second primary in head and neck region can be treated with definitive radiotherapy but the clinical outcome has been reported to be poor.

Method And Design: This is a single institutional retrospective study.

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Context: In advanced radiotherapy techniques such as three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT), geometrical uncertainties are very crucial as they may lead to under dosing of tumor and over dosing of the nearby critical structures and hence, it is important to determine planning target volume (PTV) margins which are specific for every center.

Aims: The aim of this study is to determine adequate clinical target volume (CTV) to PTV margins specific to our radiotherapy center.

Settings And Design: To calculate CTV to PTV margins for rectal cancer patients in prone position using kV cone beam CBCT data sets.

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