Molecular understanding of the compaction behavior of indomethacin polymorphs.

Polymorphs enable us to gain molecular insights into the compaction behavior of pharmaceutical powders. Two polymorphs (α and γ) of indomethacin (IMC) were investigated for in-die and out-of-die compaction behavior using compressibility, tabletability and compactibility (CTC) profile, stress-strain relationship, and Heckel, Kawakita and Walker equations. Compaction studies were performed on a fully instrumented rotary tabletting machine.

Flow and compaction behaviour of ultrafine coated ibuprofen.

Good flow and compaction properties are prerequisites for successful compaction process. Apart from initial profile, mechanical properties of pharmaceutical powders can get modified during unit processes like milling. Milled powders can exhibit a wide range of particle size distribution.

Counterintuitive compaction behavior of clopidogrel bisulfate polymorphs.

Being a density violator, clopidogrel bisulfate (CLP) polymorphic system (forms I and II) allows us to study individually the impact of molecular packing (true density) and thermodynamic properties such as heat of fusion on the compaction behavior. These two polymorphs of CLP were investigated for in-die and out-of-die compaction behavior using CTC profile, Heckel, and Walker equations. Compaction studies were performed on a fully instrumented rotary tabletting machine.