Exploring Pathways between Internalized Weight Bias, Eating Disorder Psychopathology, and Weight Loss Expectations in Treatment-Seeking Adults with Binge Eating and Obesity.

Purpose: Individuals with obesity and binge eating face weight stigma, which can lead to internalized weight bias (IWB), reinforce eating disorder (ED) pathology, and promote unrealistic weight loss expectations (WLE). Greater understanding of pathways between IWB, ED pathology, and WLE could inform interventions to promote healthy WLE and reduce IWB. This study explored pathways through which IWB directly and indirectly relates to eating pathology and WLE in treatment-seeking adults with obesity and recurrent binge eating.

Integrative Computational Framework, , Links Mutated Driver Genes to Expression Dysregulation Across 19 Cancer Types.

Though somatic mutations play a critical role in driving cancer initiation and progression, the systems-level functional impacts of these mutations-particularly, how they alter expression across the genome and give rise to cancer hallmarks-are not yet well-understood, even for well-studied cancer driver genes. To address this, we designed an integrative machine learning model, Dyscovr, that leverages mutation, gene expression, copy number alteration (CNA), methylation, and clinical data to uncover putative relationships between nonsynonymous mutations in key cancer driver genes and transcriptional changes across the genome. We applied Dyscovr pan-cancer and within 19 individual cancer types, finding both broadly relevant and cancer type-specific links between driver genes and putative targets, including a subset we further identify as exhibiting negative genetic relationships.

Orthopedic Pain Management: Tools for Practicing Critical Care Nurses.

Nurses practicing in critical care units manage all forms of traumatic, acute, and chronic pain. Chronic pain must be managed in critical care scenarios to facilitate patient comfort and eventual recovery and healing. Patients with orthopedic injuries and conditions have distinct care needs that require specialized knowledge on the provider's part.

Strategies for Health Professionals in Managing Patients and Families in Critical Care Units.

The primary objective of this article is to share effective strategies for integrating patients and their families into the critical care setting. Additionally, it aims to address lack of pain management knowledge, burnout syndrome, and stress management tactics tailored for practicing critical care registered nurses.

Temporal and regional trends in Canada for the epidemiology and management of diabetic foot ulcers.

Objective: Diabetic foot ulcers (DFUs) are a common downstream consequence of diabetes and pose significant concern to the health of affected individuals. There are currently limited data available that detail the epidemiology and inpatient burden of DFUs in Canada. This study aims to provide updated data on the epidemiological and economic burden of DFUs in Canada between 2015 and 2019.

Shedding light on the social and health realities of care-experienced young people in Western Australia: A population-level study.

Background: Young people who were in out-of-home care (OHC) face an accelerated transition to independent adulthood. Current evidence on outcomes for Australian care-leavers is scant.

Objective: This study aims to develop a better understanding of the outcomes for young people leaving care.

Lip and tongue biting in patients with a brain injury: a practical guide.

Patients who have sustained a profound brain injury often bite their lips and tongue, damaging their oral tissues. Lip and tongue biting usually occurs in patients with atypical oral reflexes and can lead to severe trauma to soft tissues, resulting in pain, lacerations, swelling, bleeding, ulceration and difficulties providing oral care. Due to the prevalence of lip and tongue biting, healthcare professionals involved in their care must be aware of the presentation, prevention and management, and when and how to refer to dental services.

An evaluation of intervention appropriateness from the perspective of parents: A peer-mediated, play-based intervention for children with ADHD.

Introduction: A peer-mediated, play-based intervention has been developed to address social participation challenges experienced by children with ADHD. To facilitate implementation into clinical practice, interventions should be evaluated for appropriateness to the end-user, as well as effectiveness. Previous research demonstrated the approach is effective for improving children's social play skills.

Correction: A multi-proxy assessment of the impact of environmental instability on Late Holocene (4500-3800 BP) Native American villages of the Georgia coast.

[This corrects the article DOI: 10.1371/journal.pone.

Long-term outcomes and patterns of relapse in patients with bilateral Wilms tumor or bilaterally predisposed unilateral Wilms tumor, a report from the COG AREN0534 study.

The objective of this study is to report the long-term timing and patterns of relapse for children enrolled in Children's Oncology Group AREN0534, a multicenter phase III clinical trial conducted from 2009 to 2015. Participants included children with bilateral Wilms tumor (BWT) or unilateral WT with genetic predisposition to develop BWT followed for up to 10 years. Smoothed hazard (risk) functions for event-free survival (EFS) were plotted so that the timing of events could be visualized, both overall and within pre-specified groups.

Partnering With Food Pantries to Disseminate and Implement Eating Disorder Interventions.

Objective: Food insecurity is associated with eating disorder psychopathology. This Spotlight describes why food pantries could be promising partners for disseminating and implementing eating disorder interventions.

Method: Researchers are increasingly collaborating with community-based organizations to improve access to health interventions, because community-based organizations overcome structural barriers to traditional healthcare by being embedded physically in the communities they serve, convenient to visit, regularly frequented, and led by trusted community members.

small RNA Pfs1 mediates transgenerational epigenetic inheritance of pathogen avoidance in through the Ephrin receptor VAB-1.

are exposed to a variety of pathogenic and non-pathogenic bacteria species in their natural environment. Correspondingly, has evolved an ability to discern between nutritive and infectious bacterial food sources. Here we show that can learn to avoid the pathogenic bacteria (PF15), and that this learned avoidance behavior is passed on to progeny for four generations, as we previously demonstrated for (PA14) and , using similar mechanisms, including the involvement of both the TGF-β ligand DAF-7 and retrotransposon-encoded virus-like particles.

Long-Term Efficacy of Tildrakizumab in the Treatment of Psoriasis.

The pathogenesis of psoriasis has been linked to autoimmune and autoinflammatory traits that result in atypical cytokine and keratinocyte activation and proliferation. Many cytokine pathways are involved in the development of inflammation with interleukin-23 (IL-23) playing a significant role in plaque-type psoriasis. Biologic agents that target specific cytokines have shown to be effective therapies in the treatment of plaque-type psoriasis over other conventional treatments such as systemic retinoids.

Correction: Research using population-based administration data integrated with longitudinal data in child protection settings: A systematic review.

[This corrects the article DOI: 10.1371/journal.pone.

Bilateral Wilms tumor with anaplasia: A report from the Children's Oncology Group Study AREN0534.

Introduction: The purpose of this study is to examine the outcomes in children with anaplastic bilateral Wilms tumor (BWT) from study AREN0534 in order to define potential prognostic factors and areas to target in future clinical trials.

Methods: Demographic and clinical data from AREN0534 study patients with anaplasia (focal anaplasia [FA], or diffuse anaplasia [DA]) were compared. Event-free survival (EFS) and overall survival (OS) were reported using Kaplan-Meier estimation with 95% confidence bands, and differences in outcomes between FA and DA compared using log-rank tests.

Dupilumab therapy for atopic dermatitis is associated with increased risk of cutaneous T cell lymphoma: A retrospective cohort study.

Background: Dupilumab, a human monoclonal antibody targeting the interleukin 4 alpha receptor, is used for treatment of moderate to severe atopic dermatitis (AD). Previous studies have reported diagnoses of cutaneous T cell lymphoma (CTCL) after dupilumab use.

Objective: Investigate the risk of CTCL after dupilumab use in patients with AD.

Expanding the Scope of Aluminum Chemistry with Noninnocent Ligands.

ConspectusAluminum is the most abundant metal in the earth's crust at 8%, and it is also widely available domestically in many countries worldwide, which ensures a stable supply chain. To further the applications of aluminum (Al), such as in catalysis and electronic and energy storage materials, there has been significant interest in the synthesis and characterization of new Al coordination compounds that can support electron transfer (ET) and proton transfer (PT) chemistry. This has been achieved using redox and chemically noninnocent ligands (NILs) combined with the highly stable M(III) oxidation state of Al and in some cases the heavier group 13 ions, Ga and In.

Improving prime editing with an endogenous small RNA-binding protein.

Prime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3' ends of CRISPR-Cas guide RNAs. To identify cellular determinants of prime editing, we developed scalable prime editing reporters and performed genome-scale CRISPR-interference screens. From these screens, a single factor emerged as the strongest mediator of prime editing: the small RNA-binding exonuclease protection factor La.

The Use of Silver Oxynitrate Wound Dressings in the Treatment of Chronic Wounds: A Feasibility Pilot Study.

Objective: To evaluate the feasibility and effectiveness of a silver oxynitrate (Ag 7 NO 11 ) dressing on wound healing in patients with stalled chronic wounds.

Methods: A prospective pilot study was conducted to determine the feasibility and effect of using silver oxynitrate dressings within an outpatient setting in Alberta, Canada. A total of 23 patients (12 women and 11 men; mean age, 66.