Publications by authors named "Parsa Taheri-Tehrani"
Background: Silicon nanopore membrane-based implantable bioartificial organs are dependent on arteriovenous implantation of a mechanically robust and biocompatible hemofilter. The hemofilter acts as a low-resistance, high-flow network, with blood flow physiology similar to arteriovenous shunts commonly created for hemodialysis access. A mock circulatory loop (MCL) that mimics shunt physiology is an essential tool for refinement and durability testing of arteriovenous implantable bioartificial organs and silicon blood-interfacing membranes.
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- Clinical islet transplantation for type 1 diabetes is hindered by the lack of pancreas donors and the necessity for lifelong immunosuppression.
- Researchers are exploring a new bioartificial pancreas (iBAP) that utilizes silicon nanopore membranes to potentially replace the need for immunosuppressants while maintaining islet function.
- Their findings indicate that for effective insulin production, specific perifusion rates must be met, with successful insulin secretion responses observed in both lab and live pig models.