Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells.

Stimulation of resting CD4 T cells with anti-CD3/CD28-coated beads leads to rapid polarization of lipid rafts (LRs). It has been postulated that a major role of costimulation is to facilitate LR aggregation. CD86 is up-regulated or expressed aberrantly on immune cells in a wide array of autoimmune and infectious diseases.

Measurement of time-dependent CP asymmetries and the CP-odd fraction in the decay B0-->D*+D*-.

We present an updated measurement of time-dependent CP asymmetries and the CP-odd fraction in the decay B0-->D*+D*- using 232x10(6)BB pairs collected by the BABAR detector at the SLAC PEP-II B factory. We determine the CP-odd fraction to be 0.125+/-0.

Improved measurements of CP-violating asymmetry amplitudes in B0-->pi+pi- decays.

We present updated measurements of the CP-violating parameters Spipi and Cpipi in B0-->pi+pi- decays. Using a sample of 227x10(6) Upsilon(4S)-->BB decays collected with the BABAR detector at the PEP-II asymmetric-energy e(+)e(-) collider at SLAC, we observe 467+/-33 signal decays and measure Spipi=-0.30+/-0.

Production and decay of xi(c)(0) at BABAR.

Using 116.1 fb(-1) of data collected by the BABAR detector, we present an analysis of xi(c)(0) production in B decays and from the cc continuum, with the xi(c)(0) decaying into omega- K+ and xi- pi+ final states. We measure the ratio of branching fractions B(xi(c)(0) --> omega- K+)/B(xi(c)(0) --> xi- pi+) spectrum is measured on and 40 MeV below the upsilon(4S) resonance.

Observation of a broad structure in the pi+ pi- J/psi mass spectrum around 4.26 GeV/c2.

We study initial-state radiation events, e+ e- --> gammaISR pi+ pi- J/psi, with data collected with the BABAR detector. We observe an accumulation of events near 4.26 GeV/c2 in the invariant-mass spectrum of pi+ pi- J/psi.

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms.

CTLA-4 and PD-1 are receptors that negatively regulate T-cell activation. Ligation of both CTLA-4 and PD-1 blocked CD3/CD28-mediated upregulation of glucose metabolism and Akt activity, but each accomplished this regulation using separate mechanisms. CTLA-4-mediated inhibition of Akt phosphorylation is sensitive to okadaic acid, providing direct evidence that PP2A plays a prominent role in mediating CTLA-4 suppression of T-cell activation.

Measurement of branching fractions and charge asymmetries in B+ decays to eta pi+, eta K+, eta rho+, and eta' pi+, and search for B0 decays to eta K0 and eta omega.

We present measurements of branching fractions and charge asymmetries for six B-meson decay modes with an eta or eta(') meson in the final state. The data sample corresponds to 232 x 10(6) BB pairs collected with the BABAR detector at the PEP-II asymmetric-energy e(+)e(-) B Factory at SLAC. We measure the branching fractions (in units of 10(-6)): B(B+ -->eta pi(+))=5.

Measurement of time-dependent CP asymmetries in B0-->D(*)+/-D+/- decays.

We present a first measurement of CP asymmetries in neutral B decays to D+D-, and updated CP asymmetry measurements in decays to D(*+)D- and D(*-)D+. We use fully reconstructed decays collected in a data sample of (232+/-3) x 10(6) gamma(4S)-->BB events in the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. We determine the time-dependent asymmetry parameters to be SD(*+)(D-)=-0.

Measurement of the Cabibbo-Kobayashi-Maskawa angle gamma in B+/--->D*K+/- decays with a Dalitz analysis of D-->K0(S)pi-pi+.

We report on a measurement of the Cabibbo-Kobayashi-Maskawa CP-violating phase gamma through a Dalitz analysis of neutral D decays to K0(S)pi-pi+ in the processes B+/- -->D*K+/-, D*-->Dpi0, Dgamma. Using a sample of 227 x 10(6) BB pairs collected by the BABAR detector, we measure the amplitude ratios r(B)=0.12+/-0.

Determination of |Vub| from measurements of the electron and neutrino momenta in inclusive semileptonic B decays.

We present a determination of the Cabibbo-Kobayashi-Maskawa matrix element |Vub| based on the analysis of semileptonic B decays from a sample of 88 x 10(6) Gamma(4S) decays collected with the BABAR detector at the SLAC PEP-II e+e- storage ring. Charmless semileptonic B decays are selected using measurements of the electron energy and the invariant mass squared of the electron-neutrino pair. We obtain |Vub| =(3.

Measles immunity testing: comparison of two measles IgG ELISAs with plaque reduction neutralisation assay.

Two commercial IgG ELISAs, one based on recombinant nucleocapsid antigen and one based on cell culture grown native virus antigens, were evaluated for measles immunity testing by comparison with plaque reduction neutralisation test (PRNT). Qualitative results of the two ELISAs showed 92% agreement with those of PRNT. The sensitivity of the two ELISAs was 89.

Identification of a novel prostate tumor target, mindin/RG-1, for antibody-based radiotherapy of prostate cancer.

Gene expression analysis showed that a human mindin homologue, mindin/RG-1, is expressed selectively in prostate tissues and that its expression level is elevated in some prostate tumors. Mindin/RG-1 protein expression is maintained in >80% of prostate cancers metastatic to bone or lymph nodes as well as in locally recurrent tumors in androgen-unresponsive patients. In contrast, mindin/RG-1 expression in other normal tissues is significantly lower than that seen in the prostate.

Search for strange-pentaquark production in e+e- annihilation at sqrt[s] = 10.58 GeV.

We search for strange-pentaquark states that have been previously reported by other experiments--the Theta (1540)(+), Xi(5)(1860)(--), and Xi(5)(1860)(0)--in 123 fb(-1) of data recorded with the BABAR detector at the PEP-II e(+)e(-) storage ring. We find no evidence for these states and set 95% confidence level upper limits on the number of Theta(1540)(+) and Xi(5)(1860)(--) pentaquarks produced per e(+)e(-) annihilation into qq and Gamma(4S) decay. For qq events the Theta(1540)(+) [Xi(5)(1860)(--)] limit is about 8 [4] times lower than the rates measured for ordinary baryons of similar mass.

Measurement of the branching fraction of Gamma(4S) --> B0B0.

We report the first measurement of the branching fraction f(00) for Gamma(4S) --> B(0)B(0). The data sample consists of 81.7 fb(-1) collected at the Gamma(4S) resonance with the BABAR detector at the SLAC PEP-II asymmetric-energy e(+)e(-) storage ring.

Improved Measurement of the Cabibbo-Kobayashi-Maskawa angle alpha using B0(B) --> rho+rho- decays.

We present results from an analysis of B(0)B(0)--> rho(+)rho(-) using 232 x 10(6) Gamma (4S) --> BB decays collected with the BABAR detector at the PEP-II asymmetric-energy B factory at SLAC. We measure the longitudinal polarization fraction f(L) = 0.978 +/- 0.

Search for the rare leptonic decay B--->tau-nutau.

We present a search for the decay B(-)--> tau(-)nu(tau) in a sample of 88.9 x 10(6) BB pairs recorded with the BABAR detector at the Stanford Linear Accelerator Center B factory. One of the two B mesons from the Gamma(4S) is reconstructed in a hadronic or a semileptonic final state, and the decay products of the other B in the event are analyzed for consistency with a B(-) --> tau(-)nu(tau) decay.

Search for lepton flavor violation in the decay tau+/- --> mu+ gamma.

A search for the nonconservation of lepton flavor number in the decay tau(+/-) --> mu(+/-) has been performed using 2.07 x 10(8) e(+ )e(-) tau(+) tau(-) events produced at a center-of-mass energy near 10.58 GeV with the BABAR detector at the PEP-II storage ring.

Branching fraction and CP asymmetries of B0-->K0(S)K0(S)K0(S).

We present measurements of the branching fraction and time-dependent CP-violating asymmetries in B0-->K0(S)K0(S)K0(S) decays based on 227 x 10(6) Upsilon4S-->BB decays collected with the BABAR detector at the PEP-II asymmetric-energy B factory at SLAC. We obtain a branching fraction of (6.9(+0.

Search for decays of B0-->e+ e-, B0-->mu+ mu-, B0-->e +/- mu-/+.

We present a search for the decays B0-->e+ e-, B0-->mu+ mu-, and B0-->e (+/-) mu (-/+) in data collected at the Upsilon(4S) resonance with the BABAR detector at the SLAC B Factory. Using a data set of 111 fb(-1), we find no evidence for a signal in any of the three channels investigated and set the following branching fraction upper limits at the 90% confidence level: B(B0-->e+ e-) < 6.1 x 10(-8), B(B0-->mu+ mu-) < 8.

Measurements of branching fractions and time-dependent CP-violating asymmetries in B --> eta'K decays.

We present measurements of the B --> eta(')K branching fractions; for B(+) --> eta(')K(+) we measure also the time-integrated charge asymmetry Alpha(ch), and for B(0) --> eta(')K(0)(S) the time-dependent CP-violation parameters S and C. The data sample corresponds to 232 x 10(6) BB pairs produced by e(+)e(-) annihilation at the Upsilon (4S). The results are Beta(B --> eta(')K(+)) = (68.

Case report: 66 year-old man with recurrent pneumonias and sinusitis.

A current myth is that Cystic Fibrosis (CF) is a disease of childhood. However, among adults with CF, 64% are between the ages of 18 and 29 years of age; 25% are between 30 and 39 years of age; 10% are between 40 and 49 years old; and 2% are 50 years of age. We report a case of a 66 year-old male with newly diagnosed cystic fibrosis after a history of recurrent pneumonias and sinusitis, with acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD).

Sex differences in the genetic basis of morning serum cortisol levels: genome-wide screen identifies two novel loci specific to women.

Context: Relatively little is known about the influence of specific genes on cortisol levels, particularly morning cortisol levels.

Objective: The objective of this study was to identify quantitative trait loci associated with morning serum cortisol levels.

Design: We carried out a genome screen for morning serum cortisol using linkage and association methods tailored for use in large pedigrees.

Branching fractions and CP asymmetries in B0-->pi0pi0, B+-->pi+pi0, and B+-->K+pi0 decays and isospin analysis of the B-->pipi system.

Based on a sample of 227 x 10(6) BB pairs collected by the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC, we measure the branching fraction B(B0-->pi(0)pi(0))=(1.17+/-0.32+/-0.

Search for factorization-suppressed B-->chi(c)K(*) decays.

We search for the factorization-suppressed decays B-->chi(c0)K(*) and B-->chi(c2)K(*), with chi(c0) and chi(c2) decaying into J/psi gamma, using a sample of 124 x 10(6) BB events collected with the BABAR detector at the PEP-II storage ring of the Stanford Linear Accelerator Center. We find no significant signal and set upper bounds for the branching fractions.

Improved measurement of CP asymmetries in B0 --> (cc)K(0(*)) decays.

We present results on time-dependent CP asymmetries in neutral B decays to several CP eigenstates. The measurements use a data sample of about 227 x 10(6) upsilon(4S) --> BB decays collected by the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. The amplitude of the CPasymmetry, sin2beta in the standard model, is derived from decay-time distributions from events in which one neutral B meson is fully reconstructed in a final state containing a charmonium meson and the other B meson is determined to be either a B0 or B0 from its decay products.