Estimating the Pathophysiology of Phonotraumatic Vocal Hyperfunction Using Ambulatory Data and a Computational Model.

Purpose: This study uses a voice production model to estimate muscle activation levels and subglottal pressure (P) in patients with phonotraumatic vocal hyperfunction (PVH), based on ambulatory measurements of sound pressure level (SPL) and spectral tilt (H-H). In addition, variations in these physiological parameters are evaluated with respect to different values of the Daily Phonotrauma Index (DPI).

Method: The study obtained ambulatory voice data from patients diagnosed with PVH and a matched control group.

Sub-milliwatt threshold power and tunable-bias all-optical nonlinear activation function using vanadium dioxide for wavelength-division multiplexing photonic neural networks.

The increasing demand for efficient hardware in neural computation highlights the limitations of electronic-based systems in terms of speed, energy efficiency, and scalability. Wavelength-division multiplexing (WDM) photonic neural networks offer a high-bandwidth, low-latency alternative but require effective photonic activation functions. Here, we propose a power-efficient and tunable-bias all-optical nonlinear activation function using vanadium dioxide (VO) for WDM photonic neural networks.

Initial experience of endoscopic thulium fiber laser enucleation of the prostate: Perioperative outcomes and learning curve.

Background: Holmium enucleation of the prostate is currently the treatment of choice for the management of complicated or drug-unresponsive lower urinary tract symptoms due to benign prostate hyperplasia (BPH). Thulium Fiber Laser (TFL) is an alternative to holmium laser and seems to be safe and effective. We aimed to report our initial experience with TFL.

Parasitism by Shimbori, 2023 (Hymenoptera: Braconidae) of three species of Guenée, 1852: effects of preferential instar and host diet.

Unlabelled: A recently discovered koinobiont parasitoid species, Shimbori, 2023, proved to be a promising biological control agent for larvae of (Walker, 1858), (Stoll, 1782), and (J.E. Smith, 1797), all well-known pests that cause critical damage to soybean and corn crops.

Artificial Diet for Immatures of Vaurie, 1978 (Coleoptera: Curculionidae), Based on a Multidimensional Model.

Pest attacks, especially by , are a factor affecting sugarcane production. As the pest's life habits make chemical control difficult, efforts are focused on finding integrated management alternatives. It is therefore essential to study the biology of , using artificial diets for rearing the insect in the laboratory.

Software codesign between end users and developers to enhance utility for biodiversity conservation.

Creating software tools that address the needs of a wide range of decision-makers requires the inclusion of differing perspectives throughout the development process. Software tools for biodiversity conservation often fall short in this regard, partly because broad decision-maker needs may exceed the toolkits of single research groups or even institutions. We show that participatory, collaborative codesign enhances the utility of software tools for better decision-making in biodiversity conservation planning, as demonstrated by our experiences developing a set of integrated tools in Colombia.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Herbal extracts in orofacial pain: a systematic review and direct and indirect meta-analysis.

The pharmaceutical industry has been primarily focused on developing synthetic drugs to address orofacial pain (OFP)-related conditions. There is limited knowledge regarding the efficacy of the use of herbal extracts in treating OFP. A systematic review and a meta-analysis of 62 randomized controlled trials assessing the analgesic effects of herbal extracts on pain intensity in various orofacial conditions was conducted.

The Natural Products Atlas 3.0: extending the database of microbially derived natural products.

The Natural Products Atlas is a database of microbially derived natural products that contains structures, producing organism taxonomy, biosynthetic and chemical ontology classifications, grouping by compound classes and cross-links to a suite of other natural product-related data resources. The database is supported by a web server that includes functionality to browse the collection, search the database using both chemical structures and text/numerical terms and visualize the chemical diversity it contains using interactive dashboards. In the current database release, we have curated 1347 papers, increasing the number of compounds to 36 545.

Nonvolatile reconfigurable polarization rotator at datacom wavelengths based on a SbSe/Si waveguide.

Silicon photonics has become a key platform for photonic integrated circuits (PICs) due to its high refractive index and compatibility with complementary metal-oxide-semiconductor manufacturing. However, the inherent birefringence in silicon waveguides requires efficient polarization management. Here, we report a reconfigurable polarization rotator (PR) using a SbSe/Si waveguide operating at datacom wavelengths (1310 nm), providing nonvolatile switching with zero static power consumption.

A computational study of the size effect of SiO spherical nanoparticles in water solvent.

Context: This study comprehensively describes the interaction between SiO spherical nanoparticles and water molecules as a solvent medium. Our goal is to provide valuable insights into the significance of nanoparticle size in understanding their behavior and the resulting changes in the physical properties of materials. Our results indicate that SiO nanoparticles exhibit a strong affinity for water, which increases with the nanoparticle size.

Perioperative and functionnal outcomes of robot-assisted laparoscopic versus open ureterovesical reimplantation for benign lower ureteral pathologies: a single-center comparative study.

Purpose: The robot-assisted laparoscopic (RALUVR) and open (OUVR) approaches have both been described for ureterovesical reimplantation to treat benign lower ureteral pathologies. Thus, we aimed to compare the perioperative and functional outcomes of RALUVR vs. OUVR.

Microbe Profile: : antibiotics for every niche.

species comprise a genus of filamentous, sporulating bacteria belonging to the phylum Actinomycetota, formerly Actinobacteria. They are found in marine and freshwater sediments and soils and associated with marine animals, insects, and plants. To date, they have mostly been studied because of their mutually beneficial symbiosis with fungus-growing ants in the tribe .

Adipocyte derived exosomes promote cell invasion and challenge paclitaxel efficacy in ovarian cancer.

Background: Epithelial ovarian cancer (EOC) is the deadliest gynaecological cancer with high mortality rates driven by the common development of resistance to chemotherapy. EOC frequently invades the omentum, an adipocyte-rich organ of the peritoneum and omental adipocytes have been implicated in promoting disease progression, metastasis and chemoresistance. The signalling mechanisms underpinning EOC omentum tropism have yet to be elucidated.

Damage control surgery in non-traumatic abdominal emergencies: prognostic value of SOFA, APACHEII, and Mannheim peritonitis index.

This study aimed to analyze the prognostic value of the SOFA, APACHE II, and MPI (Mannheim Peritonitis Index) scores in the indication for Damage Control Surgery (DCS) in non-trauma. Retrospective analysis of patients undergoing DCS between 2014 and 2019. SOFA and APACHE II scores were calculated using parameters preceding DCS, while MPI was based on surgical descriptions.

Integrating niche and occupancy models to infer the distribution of an endemic fossorial snake (Atractus lasallei).

Understanding species distribution and habitat preferences is crucial for effective conservation strategies. However, the lack of information about population responses to environmental change at different scales hinders effective conservation measures. In this study, we estimate the potential and realized distribution of Atractus lasallei, a semi-fossorial snake endemic to the northwestern region of Colombia.

Asymmetric triangular body-cover model of the vocal folds with bilateral intrinsic muscle activation.

Many voice disorders are linked to imbalanced muscle activity and known to exhibit asymmetric vocal fold vibration. However, the relation between imbalanced muscle activation and asymmetric vocal fold vibration is not well understood. This study introduces an asymmetric triangular body-cover model of the vocal folds, controlled by the activation of bilateral intrinsic laryngeal muscles, to investigate the effects of muscle imbalance on vocal fold oscillation.

Interaction of DisBa01 peptide from Bothrops alternatus venom with BRAF melanoma receptors: Modeling and molecular docking.

Metastatic melanoma is highly aggressive and challenging, often leading to a grim prognosis. Its progression is swift, especially when mutations like BRAFV600E continuously activate pathways vital for cell growth and survival. Although several treatments target this mutation, resistance typically emerges over time.

Multi-omics analysis of antagonistic interactions among free-living Pseudonocardia from diverse ecosystems.

Actinomycetes are a phylogenetically diverse bacterial group which are widely distributed across terrestrial and aquatic ecosystems. Within this order, the genus Pseudonocardia and their specialised metabolites have been the focus of previous ecological studies due to their antagonistic interactions with other microorganisms and their mutualistic interactions with insects. However, the chemical ecology of free-living Pseudonocardia remains understudied.

Continent cutaneous diversion: Unveiling the interplay of neuro-urology and oncological challenges.

Objectives: The objective of our study is to demonstrate the practical application of continent cutaneous urinary diversion (CCUD) in oncological patients, with a focus on various aspects of the procedure: surgical challenges, functional outcomes, and quality of life.

Materials And Methods: We studied the perioperative and follow-up data of patients who underwent cystectomy for cancer associated with CCUD (Mitrofanoff, Monti or Casale). We retrospectively analyzed complications within 30days and beyond 30days post-surgery.

Ti/Ta-based composite polysaccharide scaffolds for guided bone regeneration in total hip arthroplasty.

Guided bone regeneration can play an important role in orthopedic applications. This work presents the synthesis and characterization of composite scaffolds based on polysaccharides loaded with microparticles of titanium or tantalum as novel materials proposed for composite systems with promising characteristics for guided bone regeneration. Ti/Ta composite scaffolds were synthesized using chitosan and gellan gum as organic substrates and crosslinked with oxidized dextran resulting in stable inorganic-organic composites.