Publications by authors named "Parodi J"

Objective: The present study aims to analyze the effectiveness of a gait re-education program using a sequential square mat (Tapiz Fisior®, in advance SSM Fisior®) in aspects related to mobility, balance, muscle strength, and gait of elderly people.

Methods: The intervention lasted eight weeks through progressive resistance training designed specifically for older people, with an approximate duration of 30-40 min, and was carried out three times a week on non-consecutive days using the SSM Fisior®.

Result: The intervention improved gait, balance, physical performance, lower limb strength, and walking speed.

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  • Wnt signaling is linked to synaptic plasticity, but the exact mechanisms and components involved are not fully understood.
  • Researchers found that exposure to the Wnt-5a ligand changes the threshold for inducing synaptic plasticity, promoting long-term potentiation (LTP) while inhibiting long-term depression (LTD) in hippocampal CA3-CA1 synapses.
  • The study highlights that Wnt-5a signaling enhances synaptic efficacy by increasing excitatory postsynaptic potentials and involves complex interactions with JNK and NMDAR, which can be blocked by the antagonist sFRP-2.
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We aimed to assess motoric cognitive risk syndrome (MCRS) as a mortality predictor in older male adults with cancer at Centro Médico Naval (CEMENA) in Peru from 2012 to 2015. We conducted a secondary analysis of a prospective cohort within CEMENA's Geriatrics Service. We considered all-cause mortality as the primary outcome.

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  • * Participants engaged in resistance training sessions three times a week, and their physical performance was compared between an intervention group and a control group.
  • * Results showed significant improvements in various physical performance metrics, indicating that the Fisior® Mat program can effectively enhance physical abilities in older adults with PD when combined with standard physiotherapy.
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Background: The prevalence of frailty and activities of daily living (ADL) disability may be higher in high-altitude Andean regions, due to chronic hypoxia, malnutrition, and physical challenges. and their association is relevant. This study aimed to evaluate the association between frailty and ADL disability among older adults residing in the Totos district in Peru during the year 2022.

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  • *Methods*: Researchers analyzed data from 1,385 elderly patients, using statistical methods to identify correlations, specifically looking for links between thyroid function and glycemic control with a significance level of 95%.
  • *Results*: They found that subclinical hypothyroidism was significantly more common in patients with poor glycemic control, indicating that those with hypothyroidism were 2.22 times more likely to have inadequate blood sugar levels.
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  • The study is looking to see if a new program called VIDACTIVA can help older adults in Lima, Peru, who are feeling depressed, compared to regular care they usually get.
  • They will have 64 older participants split into two groups: one will get the VIDACTIVA sessions, and the other will get some basic help and be told to go to healthcare centers.
  • If this small study shows good results, they plan to do a bigger trial to see how well the VIDACTIVA program works overall.
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  • - Wnt signaling is crucial for various cellular processes, and Xenopus laevis oocytes serve as an effective model to study these mechanisms, particularly for receptors like Frizzled 7 found in the CNS.
  • - Using two-electrode voltage clamp recordings, researchers discovered that Wnt-5a affects the oocyte's membrane currents, resulting in changes to calcium-dependent currents, membrane depolarization, and alterations in potential and outward potassium currents.
  • - Wnt-5a treatment improved oocyte viability and enhanced germinal vesicle breakdown compared to the control, indicating that Wnt-5a influences oocyte structure and signaling, contributing to a deeper understanding of the Wnt pathway's cellular effects.
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Background: Dengue has emerged as an unprecedented epidemic in Peru, and it is anticipated that this issue will escalate further owing to climate change. This study aimed to determine the risk factors associated with death from dengue in patients treated at Hospital II in Pucallpa, Peru.

Methodology: This retrospective cohort study collected information from the medical records of patients with a diagnosis of dengue treated at Hospital II Pucallpa-Peru between January 2019 and March 2023.

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  • Gait speed is linked to balance disorders in older adults living at high altitudes, particularly in 12 Andean Peruvian communities.
  • A study analyzed 418 participants over 60 years old, finding that lower gait speeds correlated with a higher prevalence of balance issues.
  • The results suggest that those with intermediate and low gait speeds have a significantly increased risk of balance disorders, indicating a need for more research to develop preventative interventions for the elderly in these areas.
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Introduction: Sarcopenia and sarcopenic obesity (SO) have emerged as significant contributors to negative health outcomes in the past decade. We aimed to estimate the prevalence of probable sarcopenia, sarcopenia, and SO in a community-dwelling population of 1151 adults aged ≥55 years in Lima, Peru.

Methods: This cross-sectional study was conducted between 2018 and 2020.

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Background: There is evidence that sarcopenia and functionality are closely related. However, the association between geriatric syndromes, such as dependence, on instrumental activities and sarcopenia could be affected by the presence of certain comorbidities, such as overweight, obesity, diabetes, and chronic obstructive pulmonary disease (COPD). Therefore, the present study aimed to determine the association between instrumental activities of daily living and muscle mass in the elderly and evaluate the impact of certain comorbidities on this association.

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Background: Sarcopenia is a musculoskeletal disease involving the reduction of muscle mass, strength, and performance. Handgrip strength (HGS) measurements included in frailty assessments are great biomarkers of aging and are related to functional deficits. We assessed the association between potential influencing factors and HGS asymmetry in older Peruvian adults.

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Cell models are indispensable tools in biotechnology when investigating the functional properties of organic compounds. The emergence of various additives designed to enhance animal production has introduced the need for in-depth evaluations, which are often hindered by the complexities of testing. In this study, we harnessed cell-based models to scrutinize the impact of Solergy as a regulator of cellular metabolism with a particular focus on its modulation of glycogen and antioxidant effects.

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Objectives: To evaluate gender differences in workplace violence (WPV) against physicians and nurses in Latin America.

Study Design: Cross-sectional study.

Methods: A cross-sectional electronic survey was conducted between January 11 and February 28, 2022.

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Introduction: During the Coronavirus (COVID-19) pandemic, healthcare providers have overcome difficult experiences such as workplace violence. Nurses are particularly vulnerable to workplace violence. The objective of this study was to characterize violence and aggression against nurses during the COVID-19 pandemic in Latin America.

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Background: Residual risk management in patients with previous cardiovascular disease (CVD) is a relevant issue. Objectives: 1) to assess the residual risk of patients with CVD using the new scores developed to predict recurrent CVD events (SMART score/SMART-REACH model); 2) to determine the use of therapies with cardiovascular benefit and the achievement of therapeutic goals in patients with very high residual risk.

Methods: A multicenter, descriptive, cross-sectional study was performed.

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Alzheimer's disease (AD) represents a substantial burden to patients, their caregivers, health systems, and society in Latin America and the Caribbean (LAC). This impact is exacerbated by limited access to diagnosis, specialized care, and therapies for AD within and among nations. The region has varied geographic, ethnic, cultural, and economic conditions, which create unique challenges to AD diagnosis and management.

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Background: Sarcopenia and sarcopenic obesity (SO) have emerged as significant contributors to negative health outcomes in the past decade. However, there remains a lack of consensus on the criteria and cut-off thresholds for assessing sarcopenia and SO. Moreover, limited data are available on the prevalence of these conditions in Latin American countries.

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Objectives: To explore the experiences of older Peruvian adults living in urban areas of Lima under lockdown due to the National COVID-19 Emergency, this study analyzes how older adults (aged 60 and older) exercise agency while also living with the negative impacts of coronavirus disease 2019 (COVID-19) and related control measures.

Methods: Between August and December 2020, our research team conducted a telephone-based, qualitative study, in which we undertook semistructured interviews with a purposive sample of low-income older adults living with chronic multimorbidities and limited resources. Forty older adults, 24 women and 16 men, with a mean age of 72 years, participated in the study.

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High altitudes can cause hypobaric hypoxia, altering human physiology and the corresponding electrocardiogram (ECG). As part of the Altitude Nondifferentiated ECG Study (ANDES), this paper reviews ECG changes in subjects ascending to high altitudes. This review was conducted following PRISMA guidelines.

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Background: After the acute infection, COVID-19 can produce cardiac complications as well as long-COVID persistent symptoms. Although vaccination against COVID-19 represented a clear reduction in both mortality and ICU admissions, there is very little information on whether this was accompanied by a decrease in the prevalence of post-COVID cardiac complications. The aim of this study was to analyze the relationship between COVID-19 vaccination and the prevalence of post-COVID cardiac injury assessed by echocardiogram, and long-COVID persistent cardiac symptoms.

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Objectives: We aim to scrutinize our evolving re-intervention strategies following primary endovascular aortic aneurysm repair (EVAR) - EVAR GORE SalvAge Fabric Technique (ARAFAT), aortic sac double breasting with endograft preservation, and stent-graft explantation.

Methods: We performed 1,555 aortic interventions over the study period, including 910 EVARs. Factors associated with the need for reintervention and the likelihood of chronic fabric fatigue failure (CFFF) were investigated.

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Objectives: We aimed to evaluate the role of SARC-F and SARC-CalF scores as risk factors for mortality in adults over 60 years of age with cancer of the Centro Médico Naval (CEMENA) in Callao, Peru during 2012-2015.

Methods: We performed a secondary analysis of data from a prospective cohort carried out from September 2012 to February 2013 in the Geriatrics Department of CEMENA. The outcome variable was mortality at two years of follow-up, while the exposure variable was the risk of sarcopenia assessed using the SARC-F and SARC-CalF scales.

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