Neurostructural and neurocognitive correlates of ε4 in youth bipolar disorder.

Background: Bipolar disorder (BD) is a clinical risk factor for Alzheimer's disease (AD). Apolipoprotein E ε4 ( ε4), a genetic risk factor for AD, has been associated with brain structure and neurocognition in healthy youth.

Aims: We evaluated whether there was an association between ε4 with neurostructure and neurocognition in youth with BD.

The Effects of Psilocybin in Adults with Major Depressive Disorder and the General Population: Findings from Neuroimaging Studies.

The use of psilocybin as treatment for major depressive disorder (MDD) has been examined as a promising alternative to traditional first-line options. We reviewed existing literature to provide a synthesis of the extant neuroimaging observations with psilocybin, and to identify putative therapeutic targets for target engagement studies with psilocybin, and potentially other psychedelics. We assessed neuroimaging observations with psilocybin among participants with MDD and healthy populations.