Publications by authors named "Parnian Naji"
Pancreatic cancer is the third leading cause of cancer death in the United States, and while conventional chemotherapy remains the standard treatment, responses are poor. Safe and alternative therapeutic strategies are urgently needed . A ketogenic diet has been shown to have anti-tumor effects across diverse cancer types but will unlikely have a significant effect alone.
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- Pancreatic ductal adenocarcinoma (PDAC) has a low 5-year survival rate of 13%, and most patients develop resistance to chemotherapy.
- Researchers discovered that overexpression of isocitrate dehydrogenase 1 (IDH1) in PDAC cells helps them survive chemotherapy by aiding mitochondrial function and managing oxidative stress.
- Inhibiting IDH1 with the drug ivosidenib alongside standard chemotherapy not only boosts treatment effectiveness in lab studies but is also being tested in clinical trials for potential application in patient care.
Introduction: We aimed to calculate the Population Attributable Fraction (PAF) of cancers due to tobacco use in the Eastern Mediterranean Region (EMRO), where water-pipe smoking is prevalent but its effect was not considered in previous studies.
Aims And Methods: We applied Levin's formula to estimate PAFs of cancers due to tobacco use (defined as all type tobacco including both cigarette and water-pipe). We also calculated PAF of water-pipe smoking separately.
Objective: The current study aimed to investigate the temporal trend of in-hospital and intensive care unit (ICU) mortality of coronavirus disease 2019 (COVID-19) patients over 6 months in the spring and summer of 2021 in Iran.
Design: We performed an observational retrospective cohort study.
Setting: Qazvin Province- Iran during 6 month from April to September 2021.