Publications by authors named "Parker L Flanders"
Article Synopsis
- - The study focuses on proanthocyanidins (PACs) with A-type linkages, which are rare in nature due to the complex biosynthesis needed to form them, but they offer enhanced structural rigidity compared to the more common B-type linkages.
- - Previous research suggests that PACs with more double linkages, particularly B- and AB-type, interact more effectively with dentin type I collagen, making A-type PACs promising materials for enhancing dental treatments.
- - The researchers utilized a chemical process to convert B-type PACs into A-type analogues and confirmed their structures through spectroscopy, finding that the type of linkages affects the flexibility and conformational energy of the PACs, which is important for their
β-Lactam antibiotics comprise one of the most widely used therapeutic classes to combat bacterial infections. This general scaffold has long been known to inhibit bacterial cell wall biosynthesis by inactivating penicillin-binding proteins (PBPs); however, bacterial resistance to β-lactams is now widespread, and new strategies are urgently needed to target PBPs and other proteins involved in bacterial cell wall formation. A key requirement in the identification of strategies to overcome resistance is a deeper understanding of the roles of the PBPs and their associated proteins during cell growth and division, such as can be obtained with the use of selective chemical probes.
View Article and Find Full Text PDF