Penile prosthesis for erectile dysfunction: recommendations from the 5th International Consultation on Sexual Medicine.

Introduction: Penile prosthesis (PP) is one of the main approved therapies for erectile dysfunction (ED). Greater than 50 years of clinical use has led to considerable innovation in PP surgery and patient care.

Objectives: To summarize the current literature and provide updated clinical evidence to inform healthcare providers on best practices with PP.

The Interplay of Pollution, Child Opportunity, and High Health Care Utilization in Children With Asthma in San Diego County.

Objectives: This study aims to (1) compare air pollution and child opportunity between neighborhoods with and without high health care utilization (HHU) for asthma, and (2) compare health care utilization frequency by race, ethnicity, primary language, and insurance type at the patient level.

Methods: This retrospective cohort study examined children with asthma within the Rady Children's Health System (2015-2020) who met HHU criteria [≥2 emergency department (ED) visits in 6 months or ≥2 hospitalizations in 12 mo]. Patient addresses were geocoded to census tracts, and ArcGIS was used to map CalEnviroScore 4.

A Model of the Determinants of Maternal Mortality for Indigenous Women.

Aims: To present a model of the determinants of maternal mortality for Indigenous women-social, structural, political and biological.

Design: Non-Indigenous academicians and an Indigenous tribal citizen and scholar partnered to amplify Indigenous women's voices.

Method: With epistemic decolonisation and Indigenist feminism as our theoretical basis, we used theory derivation to create a model of the determinants of Indigenous maternal mortality.

Functional movement disorder is associated with abnormal interoceptive brain activity: a task-based functional MRI study.

Background: Aberrant interoceptive processing has been hypothesized to contribute to the pathophysiology of functional neurological disorder, although findings have been inconsistent. Here, we utilized functional magnetic resonance imaging (fMRI) to examine neural correlates of interoceptive attention - the conscious focus and awareness of bodily sensations - in functional movement disorder (FMD).

Methods: We used voxelwise analyses to compare blood oxygenation level-dependent responses between 13 adults with hyperkinetic FMD and 13 healthy controls (HCs) during a task requiring attention to different bodily sensations and to an exteroceptive stimulus.

Neutron resonance absorption imaging fully utilizing neutron energies from 1 eV to 100 keV.

A neutron resonance absorption imaging technique to visualize two-dimensional distributions with element discrimination has been developed at the Materials and Life Science Experimental Facility of the Japan Proton Accelerator Research Complex. We measured neutron transmission spectra from 1 eV to 100 keV while rotating a sample containing iron, zirconium, nickel, molybdenum, and aluminum rods. The distributions of hafnium (impurity of zirconium) and molybdenum were clearly obtained by a straightforward analysis using the most prominent resonances.

Clinical Evaluation of the Temperature Dependence of Subcutaneous Injection Experience in Healthy Volunteers.

Purpose: To evaluate the clinical effect of the warming step for subcutaneous (SC) injection on injection site pain (ISP).

Methods: A single center, randomized, partially blinded, crossover study in 44 healthy participants was conducted. Participants self-injected with autoinjectors (1 mL) with either high pain (citrate/sodium chloride (NaCl)) or low pain (mannitol) formulations at refrigerated temperature or warmed to room temperature (RT) according to the instructions for use (IFU).

Pseudo-HFOs Elimination in iEEG Recordings Using a Robust Residual-based Dictionary Learning Framework.

High-frequency oscillations (HFOs) in intracranial EEG (iEEG) recordings are critical biomarkers for localizing the seizure onset zone (SOZ) in patients with focal refractory epilepsy. Despite their clinical significance, HFO analysis is often compromised by high-frequency artifacts that bypass conventional detectors, resulting in false-positive events that dilute the reliability of the HFO pool. To address this challenge, this study aimed to develop an automated method to accurately identify and eliminate false-positive events, ensuring more robust and artifact-free HFO analysis for clinical applications.

Presence and Impact of Aldol Condensation Products as Off-Notes in Plant-Based Protein Sources.

Off-notes in plant-based sources of protein are mainly formed via the lipid oxidation of unsaturated fatty acids. During gas chromatography-olfactometry analysis of pea protein isolate, previously uncharacterized old soap odors were detected. These were found to arise from a family of α,β-unsaturated aldehydes formed from the aldol condensation of pentanal and hexanal during the protein extraction process.

Intraepithelial corneal deposits associated with Mirvetuximab soravtansine use for platinum-resistant ovarian cancer.

Purpose: Present a case of Mirvetuximab soravtansine (MIRV)-induced intraepithelial corneal deposits, review a proposed mechanism to explain the blurred vision our patient experienced, and explain clinical exams that may be used to support the diagnosis.

Observations: A 63-year-old female with metastatic ovarian cancer diagnosed with intraepithelial corneal deposits two weeks after her first MIRV infusion. Treatment with topical prednisolone acetate 1 % ophthalmic suspension and lubricating eye drops without interruption of her MIRV infusions resulted in complete resolution of blurry vision and corneal deposits.

Upskilling Rheumatology Occupational Therapists in Work Rehabilitation: An Evaluation of a Job Retention Vocational Rehabilitation Training Course (the Workwell Trial).

Objectives: The objectives were to assess current job retention vocational rehabilitation (JRVR) services for employed individuals with inflammatory arthritis (IA) in rheumatology therapy departments interested in participating in the Workwell trial. Additionally, to modify a JRVR training course to support therapists in delivering JRVR and to evaluate changes in therapists' knowledge, confidence, and ability following the training.

Methods: This was a mixed-methods study.

"It Was Like the Final Piece in the Puzzle for Me": A Qualitative Study on the Experiences of Autistic Women Initially Diagnosed with Borderline Personality Disorder.

Background: Women who self-harm and experience complex mental health difficulties are frequently diagnosed with borderline personality disorder (BPD), also known as emotionally unstable personality disorder. Emerging research suggests that self-harm may often be better explained through the lens of autism, and that greater consideration should be given to the clients' motivations for self-harm. How time alone is experienced may also be a differentiating factor.

Phytobacterial effectors antagonize plant reproduction: new weapons in hand.

Bacteria secrete proteins into plant cells to reprogram host immunity and development. Yang et al. recently revealed that a nonadapted bacterial pathogen, Xanthomonas oryzae (Xoo), suppresses reproduction in arabidopsis (Arabidopsis thaliana) via a type VI-secreted effector TleB.

The Hidden Overlap Between Patient Group Means in Bariatric Randomized Controlled Trials.

Introduction: Reliance on summary data such as averages may not fully represent the breadth of individual patient responses that occur within a randomized controlled trial. As a result, a large portion of reported patient outcomes may be reasonably expected regardless of the trial arm to which a study subject is assigned. This study aims to investigate the extent of results overlap that exists between interventions in bariatric randomized controlled trials, despite significant P values by analyzing differences in trial means and standard deviations (SDs).

Cellular-Resolution and Bulk-Fluorescence Recordings of Calcium Activity Yield Reciprocal Readouts of In Vivo Drug Efficacy.

Genetically encoded fluorescent sensors of neural activity have become a mainstay of basic neuroscience. However, preclinical drug development has been slower to adopt these tools. Recently, we used miniature microscopes to record Ca activity in D1 and D2 dopamine receptor-expressing spiny projection neurons (SPNs) in response to antipsychotic drugs or candidates.

The Past, Present, and Future of Cervical Cancer Vaccines.

Since the introduction of prophylactic HPV vaccines, both HPV infection rates and cervical cancer rates have subsequently dropped. Yet, cervical cancer remains the fourth most common cancer diagnosis in women globally. As HPV and its role in the development of cervical cancer become better understood, vaccines have emerged as a front runner for improved therapeutic cervical cancer treatment.

Intravenous Sodium Ferric Gluconate Complex for Hospitalized Pediatric Patients with Iron Deficiency Anemia.

Iron deficiency anemia is common in the pediatric population. Red blood cell transfusions, a common acute treatment, pose well-recognized risks including lung injury, circulatory overload, and immune dysfunction. Intravenous iron, specifically sodium ferric gluconate complex (SFGC), is a potential alternative, however investigation on its use in hospitalized children is lacking.

Impact of Selected Starters and Cassava Varieties on the Proximate, Rheological, and Volatile Profiles of Lafun.

Spontaneous fermentation is currently used to produce lafun from cassava, leading to inconsistent product quality and decreased safety. Using starter cultures and optimising the selection of the raw materials can overcome this. This study evaluated the impact of various lactic acid bacteria (LAB) starters and varieties of cassava (bitter: IBA30527; vitamin A fortified bitter: IBA011371; and sweet: TMEB117) on the proximate, rheological, and volatile profiles of lafun.

The International Work Addiction Scale (IWAS): A screening tool for clinical and organizational applications validated in 85 cultures from six continents.

Background And Aims: Despite the last decade's significant development in the scientific study of work addiction/workaholism, this area of research is still facing a fundamental challenge, namely the need for a valid and reliable measurement tool that shows cross-cultural invariance and, as such, allows for worldwide studies on this phenomenon.

Methods: An initial 16-item questionnaire, developed within an addiction framework, was administered alongside job stress, job satisfaction, and self-esteem measures in a total sample of 31,352 employees from six continents and 85 cultures (63.5% females, mean age of 39.

Fathers' work leave and infant breastfeeding in a state-representative sample of fathers in Georgia, United States.

Background: Breastfeeding provides multiple maternal and child benefits, but breastfeeding rates are suboptimal. Parental leave access and use have been associated with higher breastfeeding rates, however, there have been a lack of studies examining fathers' use of parental leave. The objective of this study was to measure the associations between fathers' work leave and infant breastfeeding among a representative sample of fathers from Georgia, United States.

Inhibiting mechanotransduction prevents scarring and yields regeneration in a large animal model.

Modulating mechanotransduction by inhibiting yes-associated protein (YAP) in mice yields wound regeneration without scarring. However, rodents are loose-skinned and fail to recapitulate key aspects of human wound repair. We sought to elucidate the effects of YAP inhibition in red Duroc pig wounds, the most human-like model of scarring.

Vacuum erectile devices for erectile dysfunction: recommendations from the 5th international consultation on sexual medicine.

Introduction: Vacuum erectile device (VED) is 1 of the main approved therapies for erectile dysfunction (ED). The introduction of phosphodiesterase type 5 inhibitor (PDE5i) for ED significantly changed the roles of VED in contemporary sexual medicine.

Objective: To provide updated clinical evidence to inform health care providers on best practices with VED.

Automated Insulin Delivery in Adults With Type 2 Diabetes: A Nonrandomized Clinical Trial.

Importance: There is a need for additional treatment options for people with type 2 diabetes treated with insulin. Given the limited data on the use of automated insulin delivery (AID) systems in type 2 diabetes, studies evaluating their safety and efficacy are important.

Objective: To evaluate the association of AID with hemoglobin A1c (HbA1c) levels in a diverse cohort of adults with type 2 diabetes.

Spatial Transcriptomics in Human Cardiac Tissue.

Spatial transcriptomics has transformed our understanding of gene expression by preserving the spatial context within tissues. This review focuses on the application of spatial transcriptomics in human cardiac tissues, exploring current technologies with a focus on commercially available platforms. We also highlight key studies utilizing spatial transcriptomics to investigate cardiac development, electro-anatomy, immunology, and ischemic heart disease.