Publications by authors named "Parker J Lee"
Article Synopsis
- Researchers discovered that CD163+ macrophages, which respond to hemorrhages in plaques, have an inverse relationship with VC, suggesting they may help inhibit calcification.
- The study highlighted that these macrophages regulate VC via NF-κB signaling and enhance the production of hyaluronan, an important component of the extracellular matrix, impacting plaque stability and development.
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants stresses the continued need for next-generation vaccines that confer broad protection against coronavirus disease 2019 (COVID-19). We developed and evaluated an adjuvanted SARS-CoV-2 spike ferritin nanoparticle (SpFN) vaccine in nonhuman primates. High-dose (50 μg) SpFN vaccine, given twice 28 days apart, induced a Th1-biased CD4 T cell helper response and elicited neutralizing antibodies against SARS-CoV-2 wild-type and variants of concern, as well as against SARS-CoV-1.
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- Sudden cardiac death (SCD) without an explanation is linked to genetic factors, but the relationship between specific genetic variants and unexplained SCD in White and African American adults has not been thoroughly studied before.
- A study involving 683 participants (413 with sequenced DNA) examined the frequency of pathogenic or likely pathogenic (P/LP) variants in genes related to inherited cardiomyopathies and arrhythmia syndromes among those who died from unexplained SCD.
- The results revealed that 18.4% of participants carried P/LP variants; predominantly, these were linked to hypertrophic cardiomyopathy, dilated cardiomyopathy, and long QT syndrome, highlighting a significant connection between genetic risk factors and unexpl
Unlabelled: The emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants stresses the continued need for next-generation vaccines that confer broad protection against coronavirus disease 2019 (COVID-19). We developed and evaluated an adjuvanted SARS-CoV-2 Spike Ferritin Nanoparticle (SpFN) vaccine in nonhuman primates (NHPs). High-dose (50 g) SpFN vaccine, given twice within a 28 day interval, induced a Th1-biased CD4 T cell helper response and a peak neutralizing antibody geometric mean titer of 52,773 against wild-type virus, with activity against SARS-CoV-1 and minimal decrement against variants of concern.
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- Coronary artery disease is a major health issue that significantly contributes to illness and death, with factors like intraplaque hemorrhage playing a key role in plaque development.
- The study focuses on establishing a method to assess the permeability of microvessels in fresh human coronary artery samples using the Evans Blue Dye assay, which had not been previously done.
- The protocol includes steps for perfusion of arteries, sample collection for analysis, and optional use of a mouse model to further investigate vascular permeability in different health conditions.
The last decade has witnessed the cost of drug development rise dramatically; concurrently, the number of new drug approvals has declined. Clinical trial failure rates have contributed significantly to this 'innovation' crisis and are directly related to clinical trial risk. One strategy that is often touted to resolve this challenge depends on embracing a personalized medicine approach where treatment is tailored to a patient's unique genetic background.
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