Publications by authors named "Park C"

Article Synopsis
  • Clinical images used for evaluations are often of low quality, and the research aims to create a deep learning tool to assess these images for better quality control.
  • The VGG16 model was fine-tuned with a dataset of images labeled for quality, achieving a strong performance with an area under the curve (AUC) of 0.885 in the test set and 0.864 in a separate validation set.
  • The study suggests that while users might need to take extra images, the benefits include enhanced efficiency and improved workflow for healthcare teams.
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The association of color and sound helps human cognition through a synergetic effect like intersensory facilitation. Although soft human-machine interfaces (HMIs) providing unisensory expression have been widely developed, achieving synchronized optic and acoustic expression in one device system has been relatively less explored. It is because their operating principles are different in terms of materials, and implementation has mainly been attempted through structural approaches.

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  • Head and neck dermatitis (HND) is a severe form of atopic dermatitis that primarily affects seborrheic areas and significantly impacts patients’ quality of life, with treatment being complicated by the ineffectiveness of usual topical therapies and the potential for dupilumab-associated dermatitis (DAHND).
  • Research indicates that fungi, particularly Malassezia species, play a crucial role in HND development, as they activate the immune system and cause inflammation via specific immune pathways.
  • While antifungals show promise in treating HND, particularly in oral form, the long-term effects are uncertain; new therapies like Janus kinase inhibitors and OX40 inhibitors are being explored, and factors like host microbiome variations could lead to more
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We conducted this study to assess the effects of the acute care surgery (ACS) model in the management of patients with acute appendicitis (AA) based on our 5-year single-center, retrospective experience. The current single-center, retrospective, observational study was conducted in a consecutive series of the patients with AA who had been surgically treated at a tertiary referral hospital in Seoul, Korea, between January 2016 and December 2020. At our institution, the ACS model was first introduced in March 2018.

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Sterilization and castration have been synonyms for thousands of years. Making an animal sterile meant to render them incapable of producing offspring. Castration or the physical removal of the testes was discovered to be the most simple but reliable method for managing reproduction and sexual behavior in the male.

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Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene therapy. Lipid nanoparticles (LNPs), considered a prospective vehicle for nucleic acid delivery, have demonstrated efficacy in human use during the COVID-19 pandemic. This study introduces a novel biomaterial-based platform, M1-polarized macrophage-derived cellular nanovesicle-coated LNPs (M1-C-LNPs), specifically engineered for a combined gene-immunotherapy approach against solid tumor.

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Background: The beneficial effects of fenofibrate on atherosclerotic cardiovascular disease (ASCVD) outcomes in patients with diabetes and statin treatment are unclear. We investigated the effects of fenofibrate on all-cause mortality and ASCVD in patients with diabetes, high triglyceride (TG) levels and statin treatment.

Methods: We performed a nationwide propensity-score matched (1:1) cohort study using data from the National Health Information Database in the Republic of Korea from 2010 to 2017.

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Pain is often one of the initial indicators of a viral infection, yet our understanding of how viruses induce pain is limited. Immune cells typically recognize viral nucleic acids, which activate viral receptors and signaling, leading to immunity. Interestingly, these viral receptors and signals are also present in nociceptors and are associated with pain.

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Prohibitin 1 (PHB1) is ubiquitously expressed in multiple compartments within cells and is involved in the cell cycle, cell signaling, apoptosis, transcriptional regulation, and mitochondrial biogenesis at the cellular level and in the inflammation-associated and immunological functions of B and T lymphocytes. PHB1 is an important protein that performs antioxidant regulation and immune functions inside and outside cells but has not been sufficiently studied in teleost fish. Our study aimed to elucidate the functional properties and gain new insights into the biological processes and immune system of red seabream (Pagrus major), a commercially important fish cultured in South Korea and East Asia.

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Background And Objectives: Emergency department (ED) utilization and readmission rates after spine surgery are common quality of care measures. Limited data exist on the evaluation of quality indicators after full-endoscopic spine surgery (FESS). The objective of this study was to detect rates, causes, and risk factors for unplanned postoperative clinic utilization after FESS.

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This study explores the food transport efficiency (E) in a termite tunnel consisting of a main tunnel and a 2-segment loop tunnel through a model simulation. Simulated termites navigate between the main and loop tunnels through branching nodes (a, b, c, d) with associated probabilities (P1, P2, P3, P4). The loop tunnel locations (δ) are considered: near the nest (δ = 1), at the center of the main tunnel (δ = 2), and close to the food site (δ = 3).

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The transient receptor potential ankyrin 1 (TRPA1) channel plays a pivotal role in the respiratory and gastrointestinal tracts. Within the respiratory system, TRPA1 exhibits diverse distribution patterns across key cell types, including epithelial cells, sensory nerves, and immune cells. Its activation serves as a frontline sensor for inhaled irritants, triggering immediate protective responses, and influencing airway integrity.

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Background: Carotid web (CaW)-related contrast stagnation on digital subtraction angiography (DSA) may be a marker supporting the pathophysiological theory of stasis and thrombosis/embolization. We aim to assess the correlation between DSA hemodynamic parameters with CT angiography (CTA) structural measurements and clinical characteristics.

Methods: Cross-sectional analysis of consecutive patients with CaW who underwent CTA+DSA.

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Article Synopsis
  • - This study investigated the relationship between chronic periodontitis (CP) and lung cancer using a large dataset from the Korean National Health Insurance Service, involving over 72,000 individuals with CP compared to matched controls without CP.
  • - Results showed that individuals with CP had a significantly higher risk of developing lung cancer (2.27 times more likely) during an average follow-up of 5.1 years, with the highest risks seen in those with moderate-to-severe CP, women, and never-smokers.
  • - The findings suggest that chronic periodontitis may increase lung cancer risk, highlighting the need for further research and awareness regarding oral health's impact on overall health risks.
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  • NTRK gene fusions occur in about 1% of gliomas and are considered promising targets for treatment due to their ability to cross the blood-brain barrier, leading to interest in TRK inhibitors.
  • A study of 12 NGS-verified NTRK-fused gliomas at Seoul National University Hospital found that DLGGs mostly had only NTRK fusions, while DHGGs often had additional genetic mutations, with various fusion partners identified for NTRK1 and NTRK2.
  • Treatment outcomes using TRK inhibitors varied significantly; one child with DLGG showed stable disease, while a child with DHGG and an adult with glioblastoma experienced tumor recurrence and progression, highlighting the mixed
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Chemiresistive gas sensors based on semiconducting metal oxides typically rely on noble metal catalysts to enhance their sensitivity and selectivity. However, noble metal catalysts have several drawbacks for practical utilization, including their high cost, their propensity for spontaneous agglomeration, and poisoning effects with certain types of gases. As such, in the interest of commercializing the chemiresistive gas sensor technology, we propose an alternative design for a noble-metal-free sensing material through the case study of Co-doped ceria (Co-CeO) catalysts embedded in a SnO matrix.

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Understanding the intricate details of the surface atomic structure and composition of catalysts during the oxygen evolution reaction (OER) is crucial for developing catalysts with high stability in water electrolyzers. While many notable studies highlight surface amorphization and reconstruction, systematic analytical tracing of the catalyst surface as a function of overpotential remains elusive. Heteroepitaxial (001) films of chemically stable and lattice-oxygen-inactive LaCoO are thus utilized as a model catalyst to demonstrate a series of atomic-resolution observations of the film surface at different anodic potentials.

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Rapidly fabricating flexible and stretchable sensors on nonplanar surfaces is crucial for wearable device applications. We employed a novel fabrication method, incorporating molds and gels into electroless plating, to enable direct printing of sensors on a wide array of surfaces, from those with up to 100 μm profile heights to hydrogels with a Young's modulus of 100 kPa. This coatable strain (CS) sensor offers several potential advantages.

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Article Synopsis
  • * The research finds that 15% Gd doping increases the specific capacitance of the nanoparticles to 547.8 F/g, which is five times higher than that of undoped cerium oxide (98.7 F/g).
  • * Analysis techniques like X-ray photoemission spectroscopy (XPS) and electrochemical impedance spectroscopy (EIS) indicate that oxygen vacancies at the nanoparticles' surface improve both capacitance and performance, facilitating efficient redox reactions and oxygen ion movement.
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The frequency of the apolipoprotein E ɛ4 allele and vascular risk factors differs among ethnic groups. We aimed to assess the combined effects of apolipoprotein E ɛ4 and vascular risk factors on brain age in Korean and UK cognitively unimpaired populations. We also aimed to determine the differences in the combined effects between the two populations.

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Background: Our objective was to evaluate long-term outcomes of sacral nerve stimulation (SNS) for children with functional and organic defecation disorders.

Methods: We performed a prospective study of children <21 years of age who started SNS treatment between 2012 and 2018. We recorded demographics, medical history, and diagnostic testing.

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Hydroxyapatite (HA) exhibits outstanding biocompatibility, bioactivity, osteoconductivity, and natural anti-inflammatory properties. Pure HA, ion-doped HA, and HA-polymer composites are investigated, but critical limitations such as brittleness remain; numerous efforts are being made to address them. Herein, the novel self-crystallization of a polymeric single-stranded deoxyribonucleic acid (ssDNA) without additional phosphate ions for synthesizing deoxyribonucleic apatite (DNApatite) is presented.

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Pancreatic cancer, with its alarming rising incidence, is predicted to become the second deadliest type of solid tumor by 2040, highlighting the urgent need for improved diagnostic and treatment strategies. Despite medical advancements, the five-year survival rate for pancreatic cancer remains about 14%, dropping further when metastasized. This review explores the promise of biomarkers for early detection, personalized treatment, and disease monitoring.

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The development of high-filled 3D printing resin necessitates a bonding protocol for dental indirect restorations to achieve optimal bond strength after cementation. This study evaluates shear bond strengths of high-filler 3D printed materials for permanent restorations with various surface treatments. Rodin Sculpture 1.

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