Io's tidal response precludes a shallow magma ocean.

Io experiences tidal deformation due to its eccentric orbit around Jupiter, which provides a primary energy source for Io's ongoing volcanic activity and infrared emission. The amount of tidal energy dissipated within Io is enormous and has been hypothesized to support the large-scale melting of Io's interior and the formation of a global subsurface magma ocean. If Io has a shallow global magma ocean, its tidal deformation would be much larger than in the case of a more rigid, mostly solid interior.

A multi-comprehensive approach to assess the responses of the Mediterranean mussel Mytilus galloprovincialis (Lamarck, 1919) to a simulation of a diesel-oil mixture spill.

Oil spills are a major cause of pollution impacting marine ecosystems. In this work, the effects of short-term exposure to three different concentrations of a hydrocarbon mixture (HC), that simulated the action of such an event, were investigated on Mytilus galloprovincialis specimens. Physiological effects were measured using a battery of biomarkers consisting of cellular activity (phagocytosis), immune-related enzymes, chaperonins (HSP70 and HSC70), and histomorphological alterations.

Effects of different swimming styles on postural assessment in mid-level young swimmers.

It is well-known that swimming purposes to increase the tonic-postural control. Beyond its physiological advantages, swimming also offers an exclusive platform to explore the complex interplay between body biomechanics and posture. The specific aim of this study was to investigate the effects of main swimming styles on postural balance in young athletes.

SpiroTiger and KS Brief Stimulator: Specific Devices for Breathing and Well-Being in Post-COVID-19 Patients.

Background: Post-COVID-19 patients may develop impaired lung function, with reduced lung capacities and volumes, respiratory muscle weakness, and physical inactivity. The aim of this study was to determine the effects of a detailed protocol based on breathing training with two specifically designed respiratory devices (SpiroTiger and KS Brief Stimulator) in post-COVID-19 individuals.

Methods: Sixteen young volunteers were randomly allocated into two groups: experimental ( = 8) and control ( = 8).

Cytotoxic properties of hydroalcoholic extract on androgen unresponsive prostate cancer cells.

Androgen independent phase in prostate cancer (PCa) commonly limits the therapeutic efficacy. through its main active compound, α-thujone, appears to be an option, considering its anti-proliferative, anti-metastatic and pro-apoptotic effects on hepatocellular carcinoma. However, studies on PCa are limited.

Design studies on electronics and data acquisition of a real time diamond spectrometer for the SPARC neutron camera.

The design of a compact 2 × 2 diamond matrix with independent and redundant pixels optimized for the spectrometric neutron camera of the SPARC tokamak is presented in this article. Such a matrix overcomes the constraints in dynamic range posed by the size of a single diamond sensor while keeping the ability to perform energy spectral analysis, marking a significant advancement in tokamak neutron diagnostics. A charge pre-amplifier based on radio frequency amplifiers based on InGaP technology transistors, offering up to 2 GHz bandwidth with high robustness against radiation, has been developed.

Prevalence of cumulative cardiovascular risk factors among women of childbearing age in France: Results of the GYNRISK® survey.

Global burden of cardiovascular disease is growing worldwide among women, particularly in younger women. Corresponding increases in the number and severity of cardiovascular risk factors (CVRF) associated with a greater impact in women could explain this increase in incidence. The prevalence of CVRF remains poorly known within young women, especially their cumulative prevalence.

From unimodal to multimodal dynamics of verbal and nonverbal cues during unstructured conversation.

Conversations encompass continuous exchanges of verbal and nonverbal information. Previous research has demonstrated that gestures dynamically entrain each other and that speakers tend to align their vocal properties. While gesture and speech are known to synchronize at the intrapersonal level, few studies have investigated the multimodal dynamics of gesture/speech between individuals.

A cluster of results on amplituhedron tiles.

The amplituhedron is a mathematical object which was introduced to provide a geometric origin of scattering amplitudes in super Yang-Mills theory. It generalizes and the and has a very rich combinatorics with connections to cluster algebras. In this article, we provide a series of results about tiles and tilings of the amplituhedron.

Emotional Contagion and Emotional Mimicry in Individuals with Schizophrenia: A Systematic Review.

Individuals with schizophrenia often exhibit social interaction deficits, which can affect their ability to engage effectively with others. Emotional processes, such as emotional contagion (the transfer of emotion between individuals) and emotional mimicry (the imitation of emotional expressions), are crucial for enhancing the quality of social interactions. We conducted a PubMed, Web of Science, and PsycInfo database search.

Early Penile and Donor Site Sensory Outcomes After Innervated Radial Forearm Free Flap Phalloplasty: A Pilot Prospective Study.

Background: Radial forearm free flap phalloplasty (RFFF) is a set of complex reconstructive procedures aimed at creating an aesthetic and functional penis in transgender patients. Sensory recovery in the neophallus and donor site is crucial for optimizing outcomes, but the few prior studies that exist assess neophallus sensation at limited locations and time points. The purpose of this study was to prospectively quantify sensory outcomes in the neophallus and donor site following RFFF phalloplasty.

Fundamental precision limits of fluorescence microscopy: a perspective on MINFLUX.

Over the past years, fluorescence microscopy (FM) has steadily progressed in increasing the localization precision of fluorescent emitters in biological samples and led to new claims, whose rigorous validation remains an outstanding problem. We present a novel, to the best of our knowledge, multi-parameter estimation framework that captures the full complexity of a single-emitter FM localization experiment. We showcase our method with Minimum Flux (MINFLUX) microscopy, among the highest-resolution approaches, demonstrating that (i) the localization precision can be increased only by turning the illumination intensity up, thus increasing the risk of photo-bleaching, and it is independent from the beams' separation, and (ii) in presence of background noise, the localization precision decreases with the beams' separation.

The Interplay of TLR-NFκB Signalling Pathway and Functional Immune-Related Enzymes in the Inflammatory Response of .

The close phylogenetic relationship between ascidians (Tunicata) and vertebrates makes them a powerful model for studying the innate immune system. To better understand the nature and dynamics of immune responses and the mechanisms through which bacterial infections are detected and translated into inflammation in , we applied an approach combining in vivo lipopolysaccharide (LPS) stimulation, immune-labelling techniques and functional enzymatic analyses. The immunohistochemistry showed that Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NFκB) were expressed during the inflammatory pharynx response 4 h post-LPS, with the formation of nodules in pharynx vessel lumen.

Rural veteran perception of healthcare access in South Carolina and Florida: a qualitative study.

Background: Access to mental and physical healthcare in rural areas is challenging for Veterans and their families but essential for good health. Even though recent research has revealed some of the challenges rural Veterans face accessing healthcare, a complete understanding of the gap in access is still unclear.

Methods: This qualitative study aimed to explore participants' perceptions of healthcare access.

Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation.

Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the formation of PML::RARA, an oncogenic fusion protein responsible for blocking myeloid differentiation and survival advantage. Here, we present a case of acute promyelocytic leukemia with two unusual features: basophilic differentiation and a three-way translocation involving chromosomes 12, 15 and 17.

Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review.

Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant's defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents.

Cardiac Autonomic Neuropathy in Graves' Disease: Smoking and Age as Predictive Factors.

Objectives: Hypermetabolic state in Graves' disease (GD) has a great impact on heart homeostasis, acting directly on the heart muscle and modulating the autonomic nervous system. To characterize cardiac autonomic neuropathy (CAN) as a possible complication in patients with GD.

Methods: We evaluated euthyroid GD patients and a control group of healthy euthyroid people.

Impact of age on tumor characteristics and treatment outcomes in pediatric Differentiated Thyroid Carcinoma.

Purpose: There is a tendency to use data generated for adults in the management of pediatric Differentiated Thyroid Carcinoma, neglecting the clinical peculiarities of this condition in childhood. This study aimed to assess and compare the clinical-epidemiological characteristics and their significance in the evolution of thyroid carcinoma diagnosed in childhood across different age groups.

Methods: Seventy-seven patients diagnosed with Differentiated Thyroid Carcinoma (DTC) up to 21 years old were selected and divided into different age groups: up to 10 years, 11 to 18 years, and 19 to 21 years old.

ESCRT disruption provides evidence against transsynaptic signaling functions for extracellular vesicles.

Extracellular vesicles (EVs) are released by many cell types including neurons, carrying cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular signaling or serve primarily to dispose of unwanted materials. We show that loss of multivesicular endosome-generating ESCRT (endosomal sorting complex required for transport) machinery disrupts release of EV cargoes from motor neurons.

sp. nov. Isolated from Two Cases of Bloodstream Infections in Paediatric Patients.

This study describes two cases of bacteraemia sustained by a new putative Pannonibacter species isolated at the U.O.C.