Biomimetic synthesis of nanoparticles: A comprehensive review on green synthesis of nanoparticles with a focus on Prosopis farcta plant extracts and biomedical applications.

The synthesis of nanoparticles (NPs) using environmentally friendly methods has garnered significant attention in response to concerns about the environmental impact of various nanomaterial manufacturing techniques. To address this issue, natural resources like extracts from plants, fungi, and bacteria are employed as a green alternative for nanoparticle synthesis. Plant extracts, which contain active components such as terpenoids, alkaloids, phenols, tannins, and vitamins, operate as coating and reducing agents.

Hyaluronic Acid Hydrogel Containing Resveratrol-Loaded Chitosan Nanoparticles as an Adjuvant in Atopic Dermatitis Treatment.

Atopic dermatitis (AD) is a common disease-causing skin inflammation, redness, and irritation, which can eventually result in infection that drastically impacts patient quality of life. Resveratrol (Res) is a natural phytochemical famed for its excellent anti-inflammatory and antioxidant activities. However, it is poorly bioavailable.

Spatial patterning of PCL-scaffolds directs 3D vascularized bio-constructs morphogenesis.

Modular tissue engineering (mTE) strategies aim to build three-dimensional tissue analoguesby the sapient combination of cells, micro-scaffolds (-scaffs) and bioreactors. The translation of these newly engineered tissues into current clinical approaches is, among other things, dependent on implant-to-host microvasculature integration, a critical issue for cells and tissue survival. In this work we reported, for the first time, a computer-aided modular approach suitable to build fully vascularized hybrid (biological/synthetic) constructs (bio-constructs) with micro-metric size scale control of blood vessels growth and orientation.

Edible Polymers and Secondary Bioactive Compounds for Food Packaging Applications: Antimicrobial, Mechanical, and Gas Barrier Properties.

Edible polymers such as polysaccharides, proteins, and lipids are biodegradable and biocompatible materials applied as a thin layer to the surface of food or inside the package. They enhance food quality by prolonging its shelf-life and avoiding the deterioration phenomena caused by oxidation, humidity, and microbial activity. In order to improve the biopolymer performance, antimicrobial agents and plasticizers are also included in the formulation of the main compounds utilized for edible coating packages.

Bioinspired Design of Novel Microscaffolds for Fibroblast Guidance toward Tissue Building.

Porous microscaffolds (μ-scaffs) play a crucial role in modular tissue engineering as they control cell functions and guide hierarchical tissue formation toward building new functional tissue analogues. In the present study, we developed a new route to prepare porous polycaprolactone (PCL) μ-scaffs with a bioinspired trabecular structure that supported adhesion, growth, and biosynthesis of human dermal fibroblasts (HDFs). The method involved the use of poly(ethylene oxide) (PEO) as a biocompatible porogen and a fluidic emulsion/porogen leaching/particle coagulation process to obtain spherical μ-scaffs with controllable diameter and full pore interconnectivity.

Tuning the three-dimensional architecture of supercritical CO foamed PCL scaffolds by a novel mould patterning approach.

In tissue engineering, the use of supercritical CO foaming is a valuable and widespread choice to design and fabricate porous bioactive scaffolds for cells culture and new tissue formation in three dimensions. Nevertheless, the control of scaffold pores size, shape and spatial distribution with foaming technique remains, to date, a critical limiting step. To mimic the biomimetic structure of tissues like bone, blood vessels and nerve tissues, we developed a novel supercritical CO-foaming approach for the preparation of dual-scale, dual-shape porous polymeric scaffolds with pre-defined arrays of micro-channels within a foamed porosity.

Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review.

Wound healing can lead to complex clinical problems, hence finding an efficient approach to enhance the healing process is necessary. An ideal wound dressing should treat wounds at reasonable costs, with minimal inconveniences for the patient. Chitosan is one of the most investigated biopolymers for wound healing applications due to its biocompatibility, biodegradability, non-toxicity, and antimicrobial activity.

Modular Strategies to Build Cell-Free and Cell-Laden Scaffolds towards Bioengineered Tissues and Organs.

Engineering three-dimensional (3D) scaffolds for functional tissue and organ regeneration is a major challenge of the tissue engineering (TE) community. Great progress has been made in developing scaffolds to support cells in 3D, and to date, several implantable scaffolds are available for treating damaged and dysfunctional tissues, such as bone, osteochondral, cardiac and nerve. However, recapitulating the complex extracellular matrix (ECM) functions of native tissues is far from being achieved in synthetic scaffolds.