Publications by authors named "Parisa Kangari"

Article Synopsis
  • * Mesenchymal stem cells (MSCs), which can be sourced from tissues like bone marrow and adipose, have unique properties that make them promising for cancer treatment, including their ability to differentiate into various cell types and target tumors.
  • * MSCs and their exosomes show potential in delivering therapeutic agents and inhibiting cancer progression by disrupting key signaling pathways, but challenges remain in effectively utilizing them in therapies.
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  • Meningitis and meningoencephalitis are rare but serious inflammatory conditions that have been reported following COVID-19 vaccinations, yet there's limited systematic review on these cases.
  • A thorough search of research databases led to the inclusion of 27 studies with 31 patients, highlighting symptoms like headaches and fever, with a significant number showing positive meningeal signs.
  • The majority of imaging and cerebrospinal fluid tests suggested aseptic meningitis, with around 80.6% of patients fully recovering, indicating a need for further research to clarify the relationship between these conditions and COVID-19 vaccinations.
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  • Shilajit has been traditionally used in Iranian folk medicine to treat various ailments, including bone defects, and this study investigates its effect on osteogenic differentiation of human adipose-derived mesenchymal stem cells (ASCs) in both 2D and 3D cultures.
  • In 3D culture experiments using alginate hydrogel with Shilajit, results showed enhanced alkaline phosphatase activity and increased calcium deposition, indicating that Shilajit promotes osteogenic differentiation more effectively than in 2D cultures.
  • The findings suggest that Shilajit, when combined with alginate hydrogel, can accelerate the differentiation of ASCs into bone-forming cells without altering the physical properties of the hydrogel, highlighting its potential
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Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that can cause the high rate mortality in the world. Metastasis is a significant destructive feature of tumoral cells, which directly correlates with decreased prognosis and survival. Curcumin, which is found in turmeric, has been identified as a potent therapeutic natural bioactive compound (Curcuma longa).

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Skeletal disorders are among the leading debilitating factors affecting millions of people worldwide. The use of stem cells for tissue repair has raised many promises in various medical fields, including skeletal disorders. Mesenchymal stem cells (MSCs) are multipotent stromal cells with mesodermal and neural crest origin.

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Cellular-based therapies have drawn a great deal of attention thanks to their regenerative medicine approaches to treat incurable diseases and specific injuries. In this regard, injectable cell delivery systems could actualize the therapeutically beneficial outcomes of cell-based therapeutic products. These systems have found considerable clinical uses.

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Background: Breast cancer is caused by breast tissue malignant cells and it has become one of the main medical concerns with a socio-economic significance especially for women. Among the multiple factors involved in the initiation, progression, and invasion of breast cancer, oxidative stress plays an important role. Antioxidant status, lipid peroxidation, and oxidative stress in newly diagnosed breast cancer patients were determined to find a defined pattern of oxidative stress in these patients.

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Oxidative stress is caused by an imbalance in the redox status of the body. In such a state, increase of free radicals in the body can lead to tissue damage. One of the most important species of free radicals is reactive oxygen species (ROS) produced by various metabolic pathways, including aerobic metabolism in the mitochondrial respiratory chain.

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