[Obesity and dyslipidemias].

Obesity is an important world-wide public health problem. One of the most deletereous metabolic derangements of the disease is the dyslipidemia frequently involved that is highly atherogenic. The usual phenotypic pattern is fasting hypertriglyceridemia, non-HDL post-prandial hyperlipidemia anda real increased production of small-dense LDL particles, as well as low production of HDL cholesterol.

[Hypertrophy and ventricular remodeling in systemic arterial hypertension: role of AT1 receptors].

Chronic systemic hypertension leads to structural and functional changes in the left ventricular myocardium through external and internal stimuli, altering the molecular structure of some peptides that influence hypertrophy and remodeling development. Genetic information evokes different responses in the cardiac myocyte, altering its morphology, metabolism, protein synthesis and the bioavailability of some hormonal receptors, promoting compensatory hypertrophy or apoptosis. In response to hemodynamic stress, the myocardial cell sensitizes and liberates angiotensin II (ATII) in an endogenous fashion and makes AT1 receptors to join this hormone tightly, perpetuating its deleterious effects.