A spurious haemoglobin A(1c) result associated with double heterozygote for haemoglobin Raleigh (β1[NA1]Val → Ala) and α(+)-thalassaemia.

Background: Accurate measurement of haemoglobin A(1c) (HbA(1c)) is useful for long-term glycaemic control in patients with diabetes. Many Hb variants can interfere with HbA(1c) measurement and cause inaccurate results.

Methods: The subject was a 31-year-old Thai man who was discovered because of an unexpected HbA(1c) result; other diabetic parameters were within the normal range.

False positive rates of thalassemia screening in rural clinical setting: 10-year experience in Thailand.

This retrospective study aimed to describe the magnitude of false positive screening for thalassemia in a primary care setting of Thailand. The study was conducted from 1999 to 2008 and analyzed 13,745 positive cases. It involved a combination of one tube osmotic fragility (OF) and dichlorophenol indophenol (DCIP) precipitation tests.