The influence of chrysotherapy on T-lymphocyte subpopulations in rheumatoid arthritis.

We studied the influence of chrysotherapy on lymphocytes, B-cells, T-cells, and T-lymphocyte subpopulations in 9 rheumatoid-factor-positive female patients with rheumatoid arthritis (RA). After chrysotherapy, the white blood cell count decreased within 1 month; the percentage of lymphocytes, T-cells, and B-cells did not change significantly, nor did the proportion of helper cells as determined by reactivity with monoclonal antibody OKT4. In contrast, the percentage of suppressor T-cells reactive with OKT8 was significantly decreased (p less than 0.

T-lymphocyte subpopulations in rheumatoid arthritis. II. Definition by monoclonal antibodies.

Samples of peripheral blood of 27 patients with seropositive rheumatoid arthritis (RA) and 27 healthy age- and sex-matched controls were coded and studied for lymphocyte subpopulations. Monoclonal antibodies and indirect immunofluorescence were used to analyse subpopulations of purified T cells: OKT3 reacts selectively with all peripheral human T cells, OKT4 defines the helper/inducer subpopulation and OKT8 the suppressor/cytotoxic T cells. RA patients had a significantly lower relative lymphocyte count (p less than 0.