Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution.

Cerebrovascular reactivity (CVR) is typically assessed with a carbon dioxide (CO) stimulus combined with BOLD fMRI. Recently, resting-state (RS) BOLD fMRI has been shown capable of generating CVR maps, providing a potential for broader CVR applications in neuroimaging studies. However, prior RS-CVR studies have primarily been performed at a spatial resolution of 3-4 mm voxel sizes.